語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
The impact of diabetes mellitus on s...
~
Park, Seok Won.
FindBook
Google Book
Amazon
博客來
The impact of diabetes mellitus on skeletal muscle mass and strength in older adults.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
The impact of diabetes mellitus on skeletal muscle mass and strength in older adults./
作者:
Park, Seok Won.
面頁冊數:
120 p.
附註:
Adviser: Anne B. Newman.
Contained By:
Dissertation Abstracts International67-08B.
標題:
Health Sciences, Public Health. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3232840
ISBN:
9780542858840
The impact of diabetes mellitus on skeletal muscle mass and strength in older adults.
Park, Seok Won.
The impact of diabetes mellitus on skeletal muscle mass and strength in older adults.
- 120 p.
Adviser: Anne B. Newman.
Thesis (Dr.P.H.)--University of Pittsburgh, 2006.
In older adults, diabetes is a serious public health problem because of high prevalence as well as its devastating consequences such as functional disability and high mortality. Loss of muscle mass and strength, called sarcopenia, has been considered as a common pathway leading to loss of function and frailty in older adults. We investigated the impact of diabetes on skeletal muscle mass and strength in 3,075 older adults aged 70 to 79, enrolled in the Health, Aging and Body Composition Study. Diabetes was defined not only by self report or medication use, but also by fasting plasma glucose and the result of 75-g oral glucose challenge test. Muscle mass was measured by state of the art techniques such as dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). Muscle strength was assessed quantitatively by isometric and isokinetic dynamometers. Muscle quality was defined as maximal muscle strength per unit muscle mass. In cross-sectional study, we found that muscle strength was significantly lower in men with diabetes and not higher in women with diabetes despite of having greater muscle mass than those without diabetes. Muscle quality was consistently lower in both men and women with diabetes than non-diabetic counterparts in both upper and lower extremities. We also found that longer duration (≥ 6 yrs) and poor glycemic control (A1c > 8.0%) were associated with even lower muscle quality. In longitudinal study, older adults with diabetes showed about 50% greater declines in leg muscle strength compared with those without diabetes. Leg muscle quality also declined more rapidly in older adults with diabetes. Skeletal muscle mass, estimated by DXA, declined more rapidly in older adults with diabetes. Interestingly, loss of muscle mass was more pronounced in undiagnosed diabetes. Thigh muscle area by CT declined two times faster in older women with either diagnosed or undiagnosed diabetes than non-diabetic women. The public health importance of these findings is that diabetes is clearly a risk factor for loss of muscle mass and strength in older adults. We need to develop a strategy to prevent rapid loss of muscle mass and strength in this high risk population.
ISBN: 9780542858840Subjects--Topical Terms:
1017659
Health Sciences, Public Health.
The impact of diabetes mellitus on skeletal muscle mass and strength in older adults.
LDR
:03104nam 2200277 a 45
001
969175
005
20110920
008
110921s2006 eng d
020
$a
9780542858840
035
$a
(UMI)AAI3232840
035
$a
AAI3232840
040
$a
UMI
$c
UMI
100
1
$a
Park, Seok Won.
$3
1293229
245
1 4
$a
The impact of diabetes mellitus on skeletal muscle mass and strength in older adults.
300
$a
120 p.
500
$a
Adviser: Anne B. Newman.
500
$a
Source: Dissertation Abstracts International, Volume: 67-08, Section: B, page: 4375.
502
$a
Thesis (Dr.P.H.)--University of Pittsburgh, 2006.
520
$a
In older adults, diabetes is a serious public health problem because of high prevalence as well as its devastating consequences such as functional disability and high mortality. Loss of muscle mass and strength, called sarcopenia, has been considered as a common pathway leading to loss of function and frailty in older adults. We investigated the impact of diabetes on skeletal muscle mass and strength in 3,075 older adults aged 70 to 79, enrolled in the Health, Aging and Body Composition Study. Diabetes was defined not only by self report or medication use, but also by fasting plasma glucose and the result of 75-g oral glucose challenge test. Muscle mass was measured by state of the art techniques such as dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). Muscle strength was assessed quantitatively by isometric and isokinetic dynamometers. Muscle quality was defined as maximal muscle strength per unit muscle mass. In cross-sectional study, we found that muscle strength was significantly lower in men with diabetes and not higher in women with diabetes despite of having greater muscle mass than those without diabetes. Muscle quality was consistently lower in both men and women with diabetes than non-diabetic counterparts in both upper and lower extremities. We also found that longer duration (≥ 6 yrs) and poor glycemic control (A1c > 8.0%) were associated with even lower muscle quality. In longitudinal study, older adults with diabetes showed about 50% greater declines in leg muscle strength compared with those without diabetes. Leg muscle quality also declined more rapidly in older adults with diabetes. Skeletal muscle mass, estimated by DXA, declined more rapidly in older adults with diabetes. Interestingly, loss of muscle mass was more pronounced in undiagnosed diabetes. Thigh muscle area by CT declined two times faster in older women with either diagnosed or undiagnosed diabetes than non-diabetic women. The public health importance of these findings is that diabetes is clearly a risk factor for loss of muscle mass and strength in older adults. We need to develop a strategy to prevent rapid loss of muscle mass and strength in this high risk population.
590
$a
School code: 0178.
650
4
$a
Health Sciences, Public Health.
$3
1017659
650
4
$a
Health Sciences, Medicine and Surgery.
$3
1017756
690
$a
0564
690
$a
0573
710
2 0
$a
University of Pittsburgh.
$3
958527
773
0
$t
Dissertation Abstracts International
$g
67-08B.
790
$a
0178
790
1 0
$a
Newman, Anne B.,
$e
advisor
791
$a
Dr.P.H.
792
$a
2006
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3232840
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9127665
電子資源
11.線上閱覽_V
電子書
EB W9127665
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入