東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Myostatin related gene associations ...

Walsh, Sean.

FindBook

Google Book

Amazon

博客來

Myostatin related gene associations with muscle mass and strength in humans.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Myostatin related gene associations with muscle mass and strength in humans./
作者:	Walsh, Sean.
面頁冊數:	105 p.
附註:	Adviser: Stephen M. Roth.
Contained By:	Dissertation Abstracts International67-06B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222367
ISBN:	9780542732317

Myostatin related gene associations with muscle mass and strength in humans.
Walsh, Sean.

Myostatin related gene associations with muscle mass and strength in humans. - 105 p.

Adviser: Stephen M. Roth.

Thesis (Ph.D.)--University of Maryland, College Park, 2006.

Introduction. The gradual decline in muscle mass with age is known as sarcopenia, and has been associated with an increased risk of falls, hip fractures, and functional decline. However, there is large inter-individual variability in this decline, even among people of a similar age and sex. Heritability studies have shown that genetic factors can account for up to 90% of this variation in muscle mass and &sim;65% in muscle strength. Myostatin is a negative regulator of skeletal muscle and plays a key role in muscle development and the maintenance of muscle mass. However, DNA sequence variation within this gene has not been consistently associated with skeletal muscle mass nor muscle strength in humans. Purpose. The purpose of this dissertation was to examine genetic variation in follistatin and Activin RIIB (ACVR2B), two myostatin related genes, to explore associations with skeletal muscle related phenotypes. Methods. Three hundred fifteen Caucasian males and 278 Caucasian females aged 19-90 years from the Baltimore Longitudinal Study of Aging were genotyped to determine respective haplotype groupings. Whole-body soft tissue composition was measured by dual-energy X-ray absorptiometry. Peak torque (strength) was measured using an isokinetic dynamometer. Results. Women heterozygous for ACVR2B haplotype groups 1 and 2 exhibited significantly less concentric quadriceps muscle strength than women homozygous for haplotype group 2 (108.7 +/- 2.2 vs. 118.6 +/- 4.1 N·m, .52rad/sec, respectively, p <0.05). No significant association was observed in men. However, men homozygous for follistatin haplotype group 1 exhibited significantly greater total leg FFM than men heterozygous for follistatin haplotype groups 1 and 3 (17.8 +/- 0.2 vs. 16.7 +/- 0.4 kg, respectively, p <0.05) and significantly greater total leg FFM than non-carriers of follistatin haplotype group 1 (17.8 +/- 0.2 vs. 16.5 +/- 0.5 kg, respectively, p <0.05). Moreover, male carriers of follistatin haplotype group 3 exhibited significantly less total leg FFM than non-carriers (16.6 +/- 0.3 vs. 17.5 +/- 0.2 kg, respectively, p <0.05). No significant associations between these groups were observed in women. Conclusions. The data indicate that the ACVR2B and follistatin loci may contribute to the inter-individual variation in skeletal muscle mass and strength.

ISBN: 9780542732317Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Myostatin related gene associations with muscle mass and strength in humans.
LDR:03285nam 2200289 a 45 001 969158
005 20110920
008 110921s2006 eng d
020 $a 9780542732317
035 $a (UMI)AAI3222367
035 $a AAI3222367
040 $a UMI $c UMI
100 1 $a Walsh, Sean. $3 1293213
245 1 0 $a Myostatin related gene associations with muscle mass and strength in humans.
300 $a 105 p.
500 $a Adviser: Stephen M. Roth.
500 $a Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 2947.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2006.
520 $a Introduction. The gradual decline in muscle mass with age is known as sarcopenia, and has been associated with an increased risk of falls, hip fractures, and functional decline. However, there is large inter-individual variability in this decline, even among people of a similar age and sex. Heritability studies have shown that genetic factors can account for up to 90% of this variation in muscle mass and &sim;65% in muscle strength. Myostatin is a negative regulator of skeletal muscle and plays a key role in muscle development and the maintenance of muscle mass. However, DNA sequence variation within this gene has not been consistently associated with skeletal muscle mass nor muscle strength in humans. Purpose. The purpose of this dissertation was to examine genetic variation in follistatin and Activin RIIB (ACVR2B), two myostatin related genes, to explore associations with skeletal muscle related phenotypes. Methods. Three hundred fifteen Caucasian males and 278 Caucasian females aged 19-90 years from the Baltimore Longitudinal Study of Aging were genotyped to determine respective haplotype groupings. Whole-body soft tissue composition was measured by dual-energy X-ray absorptiometry. Peak torque (strength) was measured using an isokinetic dynamometer. Results. Women heterozygous for ACVR2B haplotype groups 1 and 2 exhibited significantly less concentric quadriceps muscle strength than women homozygous for haplotype group 2 (108.7 +/- 2.2 vs. 118.6 +/- 4.1 N·m, .52rad/sec, respectively, p <0.05). No significant association was observed in men. However, men homozygous for follistatin haplotype group 1 exhibited significantly greater total leg FFM than men heterozygous for follistatin haplotype groups 1 and 3 (17.8 +/- 0.2 vs. 16.7 +/- 0.4 kg, respectively, p <0.05) and significantly greater total leg FFM than non-carriers of follistatin haplotype group 1 (17.8 +/- 0.2 vs. 16.5 +/- 0.5 kg, respectively, p <0.05). Moreover, male carriers of follistatin haplotype group 3 exhibited significantly less total leg FFM than non-carriers (16.6 +/- 0.3 vs. 17.5 +/- 0.2 kg, respectively, p <0.05). No significant associations between these groups were observed in women. Conclusions. The data indicate that the ACVR2B and follistatin loci may contribute to the inter-individual variation in skeletal muscle mass and strength.
590 $a School code: 0117.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Physiology. $3 1017816
690 $a 0369
690 $a 0433
690 $a 0719
710 2 0 $a University of Maryland, College Park. $3 657686
773 0 $t Dissertation Abstracts International $g 67-06B.
790 $a 0117
790 1 0 $a Roth, Stephen M., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3222367