東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Adrenergic receptor (ADR) genotype i...

Yao, Li Li.

FindBook

Google Book

Amazon

博客來

Adrenergic receptor (ADR) genotype influences the effects of strength training on mid-thigh intermuscular fat.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Adrenergic receptor (ADR) genotype influences the effects of strength training on mid-thigh intermuscular fat./
作者:	Yao, Li Li.
面頁冊數:	130 p.
附註:	Adviser: Ben F. Hurley.
Contained By:	Dissertation Abstracts International67-03B.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3212640
ISBN:	9780542618581

Adrenergic receptor (ADR) genotype influences the effects of strength training on mid-thigh intermuscular fat.
Yao, Li Li.

Adrenergic receptor (ADR) genotype influences the effects of strength training on mid-thigh intermuscular fat. - 130 p.

Adviser: Ben F. Hurley.

Thesis (Ph.D.)--University of Maryland, College Park, 2006.

Sarcopenia results in an increase in intermuscular fat (IMF) and low density muscle (LDM), which is associated with adverse health and functional consequences. Although strength training (ST) is considered an intervention of choice for the prevention and treatment of sarcopenia, little is known about its effect on IMF or LDM. Regional fat alterations resulting from exercise interventions may be influenced by adrenergic receptor (ADR) beta2 Gln27Glu and ADRalpha2b Glu12/Glu9 gene polymorphisms. To examine the influence of this polymorphism on mid-thigh IMF, LDM and normal density muscle (NDM), we studied 46 older men and 52 older women before and after a 10-week single leg knee extension strength training (ST) program. The ST program resulted in a substantial increase in one-repetition maximum (1-RM) strength (P = 0.0001) and NDM (P = 0.0001), but no significant changes in IMF and LDM in the whole group. However, IMF was significantly reduced with ST in subjects carrying ADRbeta2 Glu27 (-2.3 cm2, P = 0.028), but no significant change was observed with ADRbeta2 Glu27 noncarriers (+1.5 cm2, P = 0.14). The decrease in IMF in those with the ADRalpha2b Glu9 allele was approaching significance (-1.9 cm2, P = 0.066), and significantly different (-2.9 cm 2, P = 0.043) from a nonsignificant increase in IMF in the ADRalpha2b Glu9 allele noncarriers. ADRbeta2 Glu27 carriers who also carried the ADRalpha2b Glu9 allele experienced a significant loss of IMF with ST (-3.8 cm2 +/- 1.6, P = 0.018). These results suggest that the response of IMF to ST is influenced by ADRbeta2 Gln27Glu and ADRalpha2b Glu12/Glu9 polymorphisms.

ISBN: 9780542618581Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Adrenergic receptor (ADR) genotype influences the effects of strength training on mid-thigh intermuscular fat.
LDR:02558nam 2200277 a 45 001 969139
005 20110920
008 110921s2006 eng d
020 $a 9780542618581
035 $a (UMI)AAI3212640
035 $a AAI3212640
040 $a UMI $c UMI
100 1 $a Yao, Li Li. $3 1293194
245 1 0 $a Adrenergic receptor (ADR) genotype influences the effects of strength training on mid-thigh intermuscular fat.
300 $a 130 p.
500 $a Adviser: Ben F. Hurley.
500 $a Source: Dissertation Abstracts International, Volume: 67-03, Section: B, page: 1382.
502 $a Thesis (Ph.D.)--University of Maryland, College Park, 2006.
520 $a Sarcopenia results in an increase in intermuscular fat (IMF) and low density muscle (LDM), which is associated with adverse health and functional consequences. Although strength training (ST) is considered an intervention of choice for the prevention and treatment of sarcopenia, little is known about its effect on IMF or LDM. Regional fat alterations resulting from exercise interventions may be influenced by adrenergic receptor (ADR) beta2 Gln27Glu and ADRalpha2b Glu12/Glu9 gene polymorphisms. To examine the influence of this polymorphism on mid-thigh IMF, LDM and normal density muscle (NDM), we studied 46 older men and 52 older women before and after a 10-week single leg knee extension strength training (ST) program. The ST program resulted in a substantial increase in one-repetition maximum (1-RM) strength (P = 0.0001) and NDM (P = 0.0001), but no significant changes in IMF and LDM in the whole group. However, IMF was significantly reduced with ST in subjects carrying ADRbeta2 Glu27 (-2.3 cm2, P = 0.028), but no significant change was observed with ADRbeta2 Glu27 noncarriers (+1.5 cm2, P = 0.14). The decrease in IMF in those with the ADRalpha2b Glu9 allele was approaching significance (-1.9 cm2, P = 0.066), and significantly different (-2.9 cm 2, P = 0.043) from a nonsignificant increase in IMF in the ADRalpha2b Glu9 allele noncarriers. ADRbeta2 Glu27 carriers who also carried the ADRalpha2b Glu9 allele experienced a significant loss of IMF with ST (-3.8 cm2 +/- 1.6, P = 0.018). These results suggest that the response of IMF to ST is influenced by ADRbeta2 Gln27Glu and ADRalpha2b Glu12/Glu9 polymorphisms.
590 $a School code: 0117.
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Recreation. $3 1018003
690 $a 0570
690 $a 0575
710 2 0 $a University of Maryland, College Park. $3 657686
773 0 $t Dissertation Abstracts International $g 67-03B.
790 $a 0117
790 1 0 $a Hurley, Ben F., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3212640