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Maximal lactate steady state: Influe...

Mattern, Craig O'Neil.

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Maximal lactate steady state: Influence of the age-related adaptations of skeletal muscle.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Maximal lactate steady state: Influence of the age-related adaptations of skeletal muscle./
作者:	Mattern, Craig O'Neil.
面頁冊數:	49 p.
附註:	Adviser: Steven T. Devor.
Contained By:	Dissertation Abstracts International64-03B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3083780
ISBN:	9780496315871

Maximal lactate steady state: Influence of the age-related adaptations of skeletal muscle.
Mattern, Craig O'Neil.

Maximal lactate steady state: Influence of the age-related adaptations of skeletal muscle. - 49 p.

Adviser: Steven T. Devor.

Thesis (Ph.D.)--The Ohio State University, 2002.

Increased participation of aged individuals in competitive athletics warrants basic research focused on delineating age-related changes in performance variables. Purpose. Based on potential age-related declines in aerobic enzyme activities and a shift in the expression of myosin heavy chain (MHC) isoforms, we hypothesized that maximal lactate steady state (MLSS) exercise intensity would be altered as a function of age. Methods . Three age groups [(young athletes (YA), n = 10, 25.1 +/- 0.9 years, 8.3 +/- 1.0% fat) (middle-age athletes (MA), n = 10, 42.9 +/- 1.0 years, 13.6 +/- 1.9% fat) (older athletes (OA), n = 10, 63.9 +/- 2.5 years, 16.4 +/- 1.4% fat)] of male, competitive cyclists and triathletes matched for training intensity and duration were studied. Subjects performed a maximal oxygen consumption (VO2max) test followed by a series of 30 minute exercise trials to determine MLSS. The intensity of the first trial was 60% of maximal power output measured during the VO2max test. Workload of each subsequent trial was increased by 5% until blood lactate increased by ≥1 mMol/L in the last 20 minutes of the 30 minute trial. A muscle biopsy of the vastus lateralis was procured on a separate visit. Results. There were significant (p < 0.05) differences in VO 2max between all age groups (YA = 66.9 +/- 1.4 ml•kg -1•min-1, MA = 55.5 +/- 2.4 ml•kg -1•min-1, OA = 46.8 +/- 2.3 ml•kg -1•min-1). When expressed as a percentage of VO2max, there was also a significant (p < 0.05) age-related decrease in the relative MLSS exercise intensity (YA = 82.2 +/- 1.7%, MA = 76.0 +/- 1.3%, OA = 70.1 +/- 1.4%). However, there were no significant age-related changes in citrate synthase (CS) activity or MHC isoform profile. Conclusion. The hypothesis is supported as there is an age-related decline in MLSS exercise intensity in athletes matched for training intensity and duration. Additionally, the rate of this decline is approximately 3.8% per decade. While CS activity is moderately related (r = 0.44, p = 0.008) to relative MLSS intensity, it does not explain the age-related decline in MLSS. The mechanism(s) responsible for the observed age-related decline in MLSS is unknown.

ISBN: 9780496315871Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Maximal lactate steady state: Influence of the age-related adaptations of skeletal muscle.
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245 1 0 $a Maximal lactate steady state: Influence of the age-related adaptations of skeletal muscle.
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520 $a Increased participation of aged individuals in competitive athletics warrants basic research focused on delineating age-related changes in performance variables. Purpose. Based on potential age-related declines in aerobic enzyme activities and a shift in the expression of myosin heavy chain (MHC) isoforms, we hypothesized that maximal lactate steady state (MLSS) exercise intensity would be altered as a function of age. Methods . Three age groups [(young athletes (YA), n = 10, 25.1 +/- 0.9 years, 8.3 +/- 1.0% fat) (middle-age athletes (MA), n = 10, 42.9 +/- 1.0 years, 13.6 +/- 1.9% fat) (older athletes (OA), n = 10, 63.9 +/- 2.5 years, 16.4 +/- 1.4% fat)] of male, competitive cyclists and triathletes matched for training intensity and duration were studied. Subjects performed a maximal oxygen consumption (VO2max) test followed by a series of 30 minute exercise trials to determine MLSS. The intensity of the first trial was 60% of maximal power output measured during the VO2max test. Workload of each subsequent trial was increased by 5% until blood lactate increased by ≥1 mMol/L in the last 20 minutes of the 30 minute trial. A muscle biopsy of the vastus lateralis was procured on a separate visit. Results. There were significant (p < 0.05) differences in VO 2max between all age groups (YA = 66.9 +/- 1.4 ml•kg -1•min-1, MA = 55.5 +/- 2.4 ml•kg -1•min-1, OA = 46.8 +/- 2.3 ml•kg -1•min-1). When expressed as a percentage of VO2max, there was also a significant (p < 0.05) age-related decrease in the relative MLSS exercise intensity (YA = 82.2 +/- 1.7%, MA = 76.0 +/- 1.3%, OA = 70.1 +/- 1.4%). However, there were no significant age-related changes in citrate synthase (CS) activity or MHC isoform profile. Conclusion. The hypothesis is supported as there is an age-related decline in MLSS exercise intensity in athletes matched for training intensity and duration. Additionally, the rate of this decline is approximately 3.8% per decade. While CS activity is moderately related (r = 0.44, p = 0.008) to relative MLSS intensity, it does not explain the age-related decline in MLSS. The mechanism(s) responsible for the observed age-related decline in MLSS is unknown.
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