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Examining interactions at membrane s...

Baksh, Michael Mustapha.

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Examining interactions at membrane surfaces using membrane-coated silica particles.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Examining interactions at membrane surfaces using membrane-coated silica particles./
作者:	Baksh, Michael Mustapha.
面頁冊數:	96 p.
附註:	Adviser: Jay T. Groves.
Contained By:	Dissertation Abstracts International68-02B.
標題:	Biophysics, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3253760

Examining interactions at membrane surfaces using membrane-coated silica particles.
Baksh, Michael Mustapha.

Examining interactions at membrane surfaces using membrane-coated silica particles. - 96 p.

Adviser: Jay T. Groves.

Thesis (Ph.D.)--University of California, Berkeley, 2006.

Phospholipid bilayer membranes are unique, two-dimensional films whose fluid environment and highly-ordered structure are important functional characteristics endemic to biological systems. Using well-established techniques, silica particles can be coated with membranes that mimic many of these functional characteristics, creating a tool capable of sensitive, simple, label-free investigation of molecular and macroscopic interactions occurring at and between membranes. Two-dimensional dispersions of membrane-coated silica particles exhibit colloidal phase transitions that are governed by membrane surface interactions; the collective phase behavior of the beads serves as a cooperative amplifier that causes small numbers of surface events of interest to alter the macroscopic structure of the dispersion. Incorporation of specialized molecules within the bead membrane coating elicits specific biological responses from living cells and creates a system in which various physical membrane-membrane and membrane-surface interactions can be studied.Subjects--Topical Terms:

1019105
Biophysics, General.

Examining interactions at membrane surfaces using membrane-coated silica particles.
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245 1 0 $a Examining interactions at membrane surfaces using membrane-coated silica particles.
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500 $a Source: Dissertation Abstracts International, Volume: 68-02, Section: B, page: 0825.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2006.
520 $a Phospholipid bilayer membranes are unique, two-dimensional films whose fluid environment and highly-ordered structure are important functional characteristics endemic to biological systems. Using well-established techniques, silica particles can be coated with membranes that mimic many of these functional characteristics, creating a tool capable of sensitive, simple, label-free investigation of molecular and macroscopic interactions occurring at and between membranes. Two-dimensional dispersions of membrane-coated silica particles exhibit colloidal phase transitions that are governed by membrane surface interactions; the collective phase behavior of the beads serves as a cooperative amplifier that causes small numbers of surface events of interest to alter the macroscopic structure of the dispersion. Incorporation of specialized molecules within the bead membrane coating elicits specific biological responses from living cells and creates a system in which various physical membrane-membrane and membrane-surface interactions can be studied.
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