東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Molecular imaging of breast cancer u...

Yoo, Byunghee.

FindBook

Google Book

Amazon

博客來

Molecular imaging of breast cancer using PARACEST MRI.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Molecular imaging of breast cancer using PARACEST MRI./
作者:	Yoo, Byunghee.
面頁冊數:	292 p.
附註:	Adviser: Mark D. Pagel.
Contained By:	Dissertation Abstracts International68-05B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3264512
ISBN:	9780549029229

Molecular imaging of breast cancer using PARACEST MRI.
Yoo, Byunghee.

Molecular imaging of breast cancer using PARACEST MRI. - 292 p.

Adviser: Mark D. Pagel.

Thesis (Ph.D.)--Case Western Reserve University, 2007.

In Chapter VIII. Future research, the research directions in the future and tentative projects are suggested.

ISBN: 9780549029229Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Molecular imaging of breast cancer using PARACEST MRI.
LDR:03291nam 2200325 a 45 001 965669
005 20110906
008 110906s2007 eng d
020 $a 9780549029229
035 $a (UMI)AAI3264512
035 $a AAI3264512
040 $a UMI $c UMI
100 1 $a Yoo, Byunghee. $3 1288438
245 1 0 $a Molecular imaging of breast cancer using PARACEST MRI.
300 $a 292 p.
500 $a Adviser: Mark D. Pagel.
500 $a Source: Dissertation Abstracts International, Volume: 68-05, Section: B, page: 3210.
502 $a Thesis (Ph.D.)--Case Western Reserve University, 2007.
520 $a In Chapter VIII. Future research, the research directions in the future and tentative projects are suggested.
520 $a In Chapter I. Introduction, two important physiological phenomena in breast cancer, apoptosis and angiogenesis, are described. Two molecular biomarkers, caspases for apoptosis and matrix metalloproteinase's for angiogenesis, are described particularly in the context of molecular imaging detection methods. In Chapter II. Responsive MR contrast agents, the responsive contrast agents in MR imaging are reviewed based on the response mechanisms, such as tumbling time, water accessibility and water exchange rates. Detecting enzyme activity has wide applications and is a hot issue in molecular imaging research. In Chapter III. Solution phase synthesis of peptidyl contrast agents, a new facile synthetic methodology for creating peptidyl DOTA using an aminoDOTA core compound is described. The solution phase synthesis methodology has limitations for the introduction of diverse sequences of peptides on a DOTA moiety. To overcome this limitation, in Chapter IV. Solid phase synthesis of peptidyl contrast agents, a solid phase synthetic approach was investigated. The solid phase synthetic method has been applied for the synthesis of diverse peptidyl DOTA structures for research presented in this dissertation, and for other molecular imaging research.
520 $a In Chapter V. Detection of enzyme activity based on PARACESET effect, the newly synthesized caspase-3 targeting peptidyl MR contrast agent was evaluated for the physico/chemical properties. The in vitro enzyme activity detection was demonstrated using caspase-3 and the newly synthesized peptidyl DOTA MR contrast agent. Kinetics studies were conducted by measuring PARACEST effects and the PARACEST kinetics results were compared with the results from fluorescence enzyme kinetics studies.
520 $a In Chapter VI. Review of DCE-MRI contrast agents, the contrast agents used for DCE-MRI were reviewed according to the criteria of molecular weight. The conventional DCE-MRI method was implemented and tested to show the utility of this technique to study tumor angiogenesis. PARACEST DCE-MRI is new concept of DCE-MRI in many aspects. The PARACEST DCE-MRI technique was studied and the results were compared with conventional T1 DCE-MRI. The results were summarized in Chapter VII. PARACEST DCE-MRI .
590 $a School code: 0042.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0541
690 $a 0574
690 $a 0992
710 2 0 $a Case Western Reserve University. $3 1017714
773 0 $t Dissertation Abstracts International $g 68-05B.
790 $a 0042
790 1 0 $a Pagel, Mark D., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3264512