東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Advances in rapid multi-tracer posit...

Rust, Thomas Cooper.

FindBook

Google Book

Amazon

博客來

Advances in rapid multi-tracer positron emission tomography.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Advances in rapid multi-tracer positron emission tomography./
作者:	Rust, Thomas Cooper.
面頁冊數:	213 p.
附註:	Adviser: Dan J. Kadrmas.
Contained By:	Dissertation Abstracts International67-12B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3246319

Advances in rapid multi-tracer positron emission tomography.
Rust, Thomas Cooper.

Advances in rapid multi-tracer positron emission tomography. - 213 p.

Adviser: Dan J. Kadrmas.

Thesis (Ph.D.)--The University of Utah, 2007.

Positron emission tomography (PET) is an emerging clinical imaging modality that can be used to characterize many different aspects of physiology using various radiotracers. Current technology limits PET to a single tracer per imaging session, since all tracers give rise to indistinguishable 511 keV photons. This work focused primarily on the initial development of technology for rapid multi-tracer PET. In this approach, using dynamic imaging techniques and staggered tracer injections, overlapping signals from different PET tracers can be separated based on information such as tracer kinetics and half-lives. Simulation studies were performed to test the feasibility of rapid dual-tracer and triple-tracer tumor imaging using several different tracers and a parallel compartment modeling method for signal separation. This worked showed that rapid multi-tracer imaging with injections as short as 10 min apart can provide kinetic rate parameter estimates for each tracer with similar accuracy as compared to conventional single-tracer imaging. An extensive simulation study was then performed to test rapid dual-tracer PTSM + ATSM PET imaging of tumor blood flow and hypoxia as a function of injection delay, order, and relative dose for several copper isotopes. Using scans as short as 30 min, the dual-tracer method provided measures of blood flow and hypoxia similar to separate single-tracer imaging. Ongoing canine studies are being performed to further evaluate rapid PTSM + ATSM PET in a physiologically realistic model. A rapid dual-injection single-scan approach for quantification of myocardial blood flows using 13N-ammonia PET was proposed and tested using data from human subjects. Dynamic scans were acquired using imaging protocols that provided separate single-injection data as gold standards, and these data were combined to emulate rapid dual-injection imaging. Background subtraction and combined modeling methods were applied to recover rest and stress myocardial blood flow estimates, with results very similar to conventional single-injection standards. This work demonstrates that blood flow quantification can be obtained in only 20 min by the rapid dual-injection approach with accuracy similar to that of conventional separate rest and stress scans. These promising results suggest that rapid multi-tracer PET merits further development and evaluation for potential clinical use.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Advances in rapid multi-tracer positron emission tomography.
LDR:03245nam 2200265 a 45 001 965664
005 20110906
008 110906s2007 eng d
035 $a (UMI)AAI3246319
035 $a AAI3246319
040 $a UMI $c UMI
100 1 $a Rust, Thomas Cooper. $3 1288433
245 1 0 $a Advances in rapid multi-tracer positron emission tomography.
300 $a 213 p.
500 $a Adviser: Dan J. Kadrmas.
500 $a Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 7200.
502 $a Thesis (Ph.D.)--The University of Utah, 2007.
520 $a Positron emission tomography (PET) is an emerging clinical imaging modality that can be used to characterize many different aspects of physiology using various radiotracers. Current technology limits PET to a single tracer per imaging session, since all tracers give rise to indistinguishable 511 keV photons. This work focused primarily on the initial development of technology for rapid multi-tracer PET. In this approach, using dynamic imaging techniques and staggered tracer injections, overlapping signals from different PET tracers can be separated based on information such as tracer kinetics and half-lives. Simulation studies were performed to test the feasibility of rapid dual-tracer and triple-tracer tumor imaging using several different tracers and a parallel compartment modeling method for signal separation. This worked showed that rapid multi-tracer imaging with injections as short as 10 min apart can provide kinetic rate parameter estimates for each tracer with similar accuracy as compared to conventional single-tracer imaging. An extensive simulation study was then performed to test rapid dual-tracer PTSM + ATSM PET imaging of tumor blood flow and hypoxia as a function of injection delay, order, and relative dose for several copper isotopes. Using scans as short as 30 min, the dual-tracer method provided measures of blood flow and hypoxia similar to separate single-tracer imaging. Ongoing canine studies are being performed to further evaluate rapid PTSM + ATSM PET in a physiologically realistic model. A rapid dual-injection single-scan approach for quantification of myocardial blood flows using 13N-ammonia PET was proposed and tested using data from human subjects. Dynamic scans were acquired using imaging protocols that provided separate single-injection data as gold standards, and these data were combined to emulate rapid dual-injection imaging. Background subtraction and combined modeling methods were applied to recover rest and stress myocardial blood flow estimates, with results very similar to conventional single-injection standards. This work demonstrates that blood flow quantification can be obtained in only 20 min by the rapid dual-injection approach with accuracy similar to that of conventional separate rest and stress scans. These promising results suggest that rapid multi-tracer PET merits further development and evaluation for potential clinical use.
590 $a School code: 0240.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0541
690 $a 0574
710 2 0 $a The University of Utah. $3 1017410
773 0 $t Dissertation Abstracts International $g 67-12B.
790 $a 0240
790 1 0 $a Kadrmas, Dan J., $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3246319