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Solid lipid nanoparticles for topica...

Zhang, Jin.

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Solid lipid nanoparticles for topical drug delivery.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Solid lipid nanoparticles for topical drug delivery./
作者:	Zhang, Jin.
面頁冊數:	226 p.
附註:	Adviser: Eric Smith.
Contained By:	Dissertation Abstracts International67-12B.
標題:	Health Sciences, Pharmacy. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3245453

Solid lipid nanoparticles for topical drug delivery.
Zhang, Jin.

Solid lipid nanoparticles for topical drug delivery. - 226 p.

Adviser: Eric Smith.

Thesis (Ph.D.)--University of South Carolina, 2006.

Corticosteroids are therapeutic agents widely used in the pharmacological treatment of skin diseases such as eczema or psoriasis. Unfortunately, their use is restricted by the side effects which frequently occur at the systemic level. Solid Lipid Nanoparticles (SLN) have gained recognition as a potential controlled drug delivery system for topically applied drugs, which may improve the efficacy and reduce the side effects of corticosteroids. The goal of the research described here was to develop and characterize a SLN system containing corticosteroids for prolonged and localized delivery of the active drugs into the skin.Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Solid lipid nanoparticles for topical drug delivery.
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245 1 0 $a Solid lipid nanoparticles for topical drug delivery.
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500 $a Adviser: Eric Smith.
500 $a Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 7031.
502 $a Thesis (Ph.D.)--University of South Carolina, 2006.
520 $a Corticosteroids are therapeutic agents widely used in the pharmacological treatment of skin diseases such as eczema or psoriasis. Unfortunately, their use is restricted by the side effects which frequently occur at the systemic level. Solid Lipid Nanoparticles (SLN) have gained recognition as a potential controlled drug delivery system for topically applied drugs, which may improve the efficacy and reduce the side effects of corticosteroids. The goal of the research described here was to develop and characterize a SLN system containing corticosteroids for prolonged and localized delivery of the active drugs into the skin.
520 $a This study demonstrated that a 'solvent diffusion method' represented a viable new alternative for preparing topical formulation SLN. The physicochemical properties of the SLN were found to be influenced by the variation of process parameters such as injected solvents, lipid concentrations, surfactant concentrations, temperature and stirring speeds. Therefore, a Central Composite Design was applied to study how the response of interest was influenced by several variables. Lipid concentration and temperature seem to be the crucial parameters for the particle size of the monostearin SLN, however neither of these factors had a significant quadratic relationship with the zeta potential. Monostearin SLN suspensions showed high encapsulation efficiency determined by a fully-validated extraction method, while beeswax SLN suspension formulated under the same conditions had a significantly lower drug loading. Furthermore, the morphology of monostearin SLN was examined using Transmission Electron Microscopy as an aid to possibly determining the controlled drug delivery mechanism.
520 $a In vitro measurements of betamethasone 17-valerate permeation through four types of membranes were conducted using static Franz diffusion cells. Monostearin SLN showed remarkable controlled release properties and a significant epidermis drug reservoir. On the other hand, beeswax SLN was not able to reduce the drug permeation through the skin, nor increase the drug content in the upper layers of the skin. It appears, therefore, that the diffusion of corticosteroids into the skin may be manipulated by the lipid composition of the monostearin SLN. It is hoped, with further research in this delivery system, that new and improved topical products may be formulated for treating dermatological conditions.
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