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Phospholipase D couples survival and...

City University of New York.

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Phospholipase D couples survival and invasion in cancers: Possible answer to the cancer progression puzzle.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Phospholipase D couples survival and invasion in cancers: Possible answer to the cancer progression puzzle./
Author:	Zheng, Yang.
Description:	108 p.
Notes:	Adviser: David Foster.
Contained By:	Dissertation Abstracts International67-12B.
Subject:	Health Sciences, Oncology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3245077

Phospholipase D couples survival and invasion in cancers: Possible answer to the cancer progression puzzle.
Zheng, Yang.

Phospholipase D couples survival and invasion in cancers: Possible answer to the cancer progression puzzle. - 108 p.

Adviser: David Foster.

Thesis (Ph.D.)--City University of New York, 2007.

Metastasis is a late stage of malignant cancer. However, recent evidence suggests that mutations contributing to metastasis may be acquired by cancer cells at much earlier stage. This has been referred to as the cancer progression puzzle. Phospholipase D (PLD) is a ubiquitous enzyme that hydrolyzes phosphatidylcholine to produce phosphatidic acid (PA) and choline where PA is considered to be the critical lipid second messenger. Both PLD expression level and enzymatic activity are elevated in variety of human cancers. We have shown that, under the stress condition of serum withdrawal, PLD activity is elevated and provides a survival signal in the human breast cancer cell line MDA-MB-231, likely to be critical early in the tumor progression, to suppress default apoptotic programs. Of the significance, we also found that the elevated PLD activity enhances the invasive behavior of MDA-MB-231 cells, thus linking the early survival advantage with later metastatic potential. Serum reduction in culture is similar to the conditions endured by early stage cancer cells in an unvascularized solid tumor, where there is a lack of growth factors and nutrients. Under such conditions, we hypothesize that some cancer cells respond by elevating their PLD activity. These cells would have a better chance at not only surviving, but also migrating to new sites and forming new colonies where blood supply is available. Further mutations among the population of these colonies would further advance progression to malignant cancer. This hypothesis provides a possible answer to the cancer progression puzzle. We propose that some malignant cancers acquire at least part of the metastatic capability at an early stage of tumorigenesis, by selection for the survival of the emerging cancer cell, against the pressure of a poor blood supply in poorly vascularized tumors.Subjects--Topical Terms:

1018566
Health Sciences, Oncology.

Phospholipase D couples survival and invasion in cancers: Possible answer to the cancer progression puzzle.
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035 $a (UMI)AAI3245077
035 $a AAI3245077
040 $a UMI $c UMI
100 1 $a Zheng, Yang. $3 1287177
245 1 0 $a Phospholipase D couples survival and invasion in cancers: Possible answer to the cancer progression puzzle.
300 $a 108 p.
500 $a Adviser: David Foster.
500 $a Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 6909.
502 $a Thesis (Ph.D.)--City University of New York, 2007.
520 $a Metastasis is a late stage of malignant cancer. However, recent evidence suggests that mutations contributing to metastasis may be acquired by cancer cells at much earlier stage. This has been referred to as the cancer progression puzzle. Phospholipase D (PLD) is a ubiquitous enzyme that hydrolyzes phosphatidylcholine to produce phosphatidic acid (PA) and choline where PA is considered to be the critical lipid second messenger. Both PLD expression level and enzymatic activity are elevated in variety of human cancers. We have shown that, under the stress condition of serum withdrawal, PLD activity is elevated and provides a survival signal in the human breast cancer cell line MDA-MB-231, likely to be critical early in the tumor progression, to suppress default apoptotic programs. Of the significance, we also found that the elevated PLD activity enhances the invasive behavior of MDA-MB-231 cells, thus linking the early survival advantage with later metastatic potential. Serum reduction in culture is similar to the conditions endured by early stage cancer cells in an unvascularized solid tumor, where there is a lack of growth factors and nutrients. Under such conditions, we hypothesize that some cancer cells respond by elevating their PLD activity. These cells would have a better chance at not only surviving, but also migrating to new sites and forming new colonies where blood supply is available. Further mutations among the population of these colonies would further advance progression to malignant cancer. This hypothesis provides a possible answer to the cancer progression puzzle. We propose that some malignant cancers acquire at least part of the metastatic capability at an early stage of tumorigenesis, by selection for the survival of the emerging cancer cell, against the pressure of a poor blood supply in poorly vascularized tumors.
590 $a School code: 0046.
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0379
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710 2 0 $a City University of New York. $3 1018111
773 0 $t Dissertation Abstracts International $g 67-12B.
790 $a 0046
790 1 0 $a Foster, David, $e advisor
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3245077