東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Novel amphiphilic scorpion-like macr...

Tao, Li.

FindBook

Google Book

Amazon

博客來

Novel amphiphilic scorpion-like macromolecules (AScM) and amphiphilic star-like macromolecules (ASM): Physico-chemical characterizations and applications in stabilized colloidal drug delivery systems.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Novel amphiphilic scorpion-like macromolecules (AScM) and amphiphilic star-like macromolecules (ASM): Physico-chemical characterizations and applications in stabilized colloidal drug delivery systems./
作者:	Tao, Li.
面頁冊數:	241 p.
附註:	Adviser: Kathryn E. Uhrich.
Contained By:	Dissertation Abstracts International67-01B.
標題:	Health Sciences, Pharmacy. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3203408
ISBN:	9780542514173

Novel amphiphilic scorpion-like macromolecules (AScM) and amphiphilic star-like macromolecules (ASM): Physico-chemical characterizations and applications in stabilized colloidal drug delivery systems.
Tao, Li.

Novel amphiphilic scorpion-like macromolecules (AScM) and amphiphilic star-like macromolecules (ASM): Physico-chemical characterizations and applications in stabilized colloidal drug delivery systems. - 241 p.

Adviser: Kathryn E. Uhrich.

Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 2006.

AScMs and ASMs are two new series of amphiphilic macromolecules that have great potential as drug delivery systems. Both macromolecules form a core-shell micellar structure in aqueous medium, whereas AScMs aggregate to form polymeric micelles, and the ASMs have a covalently bound core structure and behave as unimolecular micelles.

ISBN: 9780542514173Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Novel amphiphilic scorpion-like macromolecules (AScM) and amphiphilic star-like macromolecules (ASM): Physico-chemical characterizations and applications in stabilized colloidal drug delivery systems.
LDR:03618nam 2200289 a 45 001 964029
005 20110901
008 110901s2006 eng d
020 $a 9780542514173
035 $a (UMI)AAI3203408
035 $a AAI3203408
040 $a UMI $c UMI
100 1 $a Tao, Li. $3 1065339
245 1 0 $a Novel amphiphilic scorpion-like macromolecules (AScM) and amphiphilic star-like macromolecules (ASM): Physico-chemical characterizations and applications in stabilized colloidal drug delivery systems.
300 $a 241 p.
500 $a Adviser: Kathryn E. Uhrich.
500 $a Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0205.
502 $a Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 2006.
520 $a AScMs and ASMs are two new series of amphiphilic macromolecules that have great potential as drug delivery systems. Both macromolecules form a core-shell micellar structure in aqueous medium, whereas AScMs aggregate to form polymeric micelles, and the ASMs have a covalently bound core structure and behave as unimolecular micelles.
520 $a AScMs have versatile structures that generate polymeric micelles with a wide range of CMC values (10-4-10-7 M), which influences their thermodynamic and kinetic stability. Some AScM polymeric micelles have free energy of micellization much lower than surfactant micelles (-23&sim; -39 kJ/mol), and show slower dissociation kinetics upon drastic dilution. The ASM unimolecular micelles are inherently stable to temperature and concentration. Sizes of both micelles fall between 10&sim;20 nm in aqueous solution, which remained constant for 3 weeks at room temperature. Structural versatility of AScMs and ASMs also facilitate tailoring drug/micelle compatibility and drug loading. Hydrophobic drugs suloctidil and triclosan interact with the micellar systems differently: triclosan achieves 61% w/w loading within AScM M12P5 polymeric micelles and shows selectivity among micelles; whereas suloctidil had lower loadings without obvious selectivity. On the other hand, both drugs achieve 20-30% w/w loading within ASM unimolecular micelles. Differences in drug/micelle compatibility also result in rapid and sustained release kinetics for suloctidil and triclosan, respectively. Hemolytic activity evaluation concludes that AScMs with long acyl chains are hemolytic; whereas the ASMs are non-hemolytic due to the covalently bound core structures. Therefore, the ASMs are deemed more suitable as injectable drug delivery systems.
520 $a M12P5 can incorporated into DPPC liposomes to achieve steric stabilization. The incorporation of M12P5 into the DPPC bilayers is exothermic and spontaneous. Compared to unmodified DPPC vesicles, M12P5-DPPC liposomes maintain satisfactory colloidal stability, significantly reduce liposomal membrane permeability, and significantly inhibit in vitro cellular uptake by J774A.1 macrophages. Compared to PEG5000-DPPE which is widely used to prepare stabilized liposomes, M12P5 bind to the DPPC bilayers with greater affinity; upon dilution, M12P5-DPPC liposomes quantitatively retained incorporated M12P5 that ensures continued liposome-stabilization effect, whereas PEG5000-DPPE suffered significant loss. Therefore, M12P5 offers better alternative to PEG5000-DPPE to sterically stabilize DPPC liposomes.
590 $a School code: 0190.
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0572
710 2 0 $a Rutgers The State University of New Jersey - New Brunswick. $3 1017590
773 0 $t Dissertation Abstracts International $g 67-01B.
790 $a 0190
790 1 0 $a Uhrich, Kathryn E., $e advisor
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3203408