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Controlling membrane organization: C...

Cambrea, Lee R.

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Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers./
作者:	Cambrea, Lee R.
面頁冊數:	171 p.
附註:	Adviser: Jennifer S. Hovis.
Contained By:	Dissertation Abstracts International68-10B.
標題:	Chemistry, Analytical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3287262
ISBN:	9780549303213

Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.
Cambrea, Lee R.

Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers. - 171 p.

Adviser: Jennifer S. Hovis.

Thesis (Ph.D.)--Purdue University, 2007.

Cells are not at equilibrium; ion concentrations continuously fluctuate and molecules are transported, created, and destroyed leading to the dynamic environment necessary for life. Even the lipid composition of the cell membrane is known to vary throughout the lifetime of the cell; however, the effects of this variation on cellular function are generally unknown. Fluorescence recovery after photobleaching (FRAP), epi-fluorescence microscopy, confocal microscopy, and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) have been used to examine effect of lipid chemistries, heat, and ionic strength on the properties of supported lipid bilayers. It will be demonstrated that ATR-FTIR spectroscopy can be successfully used to obtain information about the conformation of lipid head groups (e.g. CN+C, PO 2-), the hydration/hydrogen-bonding between and around lipids (e.g. CO, PO2-), and the orientation/conformation of the hydrocarbon chains (e.g. CH2, CH3).

ISBN: 9780549303213Subjects--Topical Terms:

586156
Chemistry, Analytical.

Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.
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100 1 $a Cambrea, Lee R. $3 1285851
245 1 0 $a Controlling membrane organization: Chemical and spectroscopic properties of lipid bilayers.
300 $a 171 p.
500 $a Adviser: Jennifer S. Hovis.
500 $a Source: Dissertation Abstracts International, Volume: 68-10, Section: B, page: 6632.
502 $a Thesis (Ph.D.)--Purdue University, 2007.
520 $a Cells are not at equilibrium; ion concentrations continuously fluctuate and molecules are transported, created, and destroyed leading to the dynamic environment necessary for life. Even the lipid composition of the cell membrane is known to vary throughout the lifetime of the cell; however, the effects of this variation on cellular function are generally unknown. Fluorescence recovery after photobleaching (FRAP), epi-fluorescence microscopy, confocal microscopy, and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) have been used to examine effect of lipid chemistries, heat, and ionic strength on the properties of supported lipid bilayers. It will be demonstrated that ATR-FTIR spectroscopy can be successfully used to obtain information about the conformation of lipid head groups (e.g. CN+C, PO 2-), the hydration/hydrogen-bonding between and around lipids (e.g. CO, PO2-), and the orientation/conformation of the hydrocarbon chains (e.g. CH2, CH3).
520 $a Results will also be presented demonstrating that it is possible to create both reversible and irreversible changes to the membrane organization and curvature through use of a biologically relevant process, fluctuations in the bulk ionic strength. Also demonstrated is the ability to control the fluidity of phase separation within a binary lipid mixture by alterations to the lipid compositions.
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773 0 $t Dissertation Abstracts International $g 68-10B.
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791 $a Ph.D.
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