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Angle-resolved optical coherence tom...

Desjardins, Adrien Emmanuel.

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Angle-resolved optical coherence tomography.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Angle-resolved optical coherence tomography./
作者:	Desjardins, Adrien Emmanuel.
面頁冊數:	149 p.
附註:	Advisers: Brett E. Bouma; Guillermo J. Tearney.
Contained By:	Dissertation Abstracts International68-05B.
標題:	Biophysics, Medical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3265165
ISBN:	9780549024705

Angle-resolved optical coherence tomography.
Desjardins, Adrien Emmanuel.

Angle-resolved optical coherence tomography. - 149 p.

Advisers: Brett E. Bouma; Guillermo J. Tearney.

Thesis (Ph.D.)--Harvard University, 2007.

Optical coherence tomography (OCT) has emerged as a powerful tool for probing the microstructure of biological tissue non-invasively at high-speed. OCT measures depth-resolved reflectance of infrared light, generating cross-sectional images non-invasively with micron-scale resolution. As with other imaging modalities that employ coherent detection, OCT images are confounded by speckle noise. Speckle imposes a grainy texture on images that reduces the signal-to-noise ratio to near unity values. As a result, it conceals subtle differences in scattering properties known to be crucial for differentiating normal from diseased tissue states. In this thesis, we developed a novel OCT modality called "Angle-Resolved OCT" in which depth scans (A-lines) are obtained simultaneously from a broad range of backscattering angles. We demonstrated that high levels of speckle reduction can be achieved by averaging the magnitudes of A-lines corresponding to the same transverse locations. With both experimental and analytic approaches, we demonstrated that this averaging method does not lead to a substantial loss in spatial resolution. We developed two different imaging systems for performing Angle-Resolved OCT. With the first system, angular data was acquired simultaneously; with the second, it was acquired sequentially. The first system had superior speckle-reduction capabilities but image quality degraded significantly with small sample movements. The second system allowed for in vivo imaging, as demonstrated with Resolved OCT systems, the speckle-reduced images showed hitherto unprecedented delineation of tissue microstructure.

ISBN: 9780549024705Subjects--Topical Terms:

1017681
Biophysics, Medical.

Angle-resolved optical coherence tomography.
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502 $a Thesis (Ph.D.)--Harvard University, 2007.
520 $a Optical coherence tomography (OCT) has emerged as a powerful tool for probing the microstructure of biological tissue non-invasively at high-speed. OCT measures depth-resolved reflectance of infrared light, generating cross-sectional images non-invasively with micron-scale resolution. As with other imaging modalities that employ coherent detection, OCT images are confounded by speckle noise. Speckle imposes a grainy texture on images that reduces the signal-to-noise ratio to near unity values. As a result, it conceals subtle differences in scattering properties known to be crucial for differentiating normal from diseased tissue states. In this thesis, we developed a novel OCT modality called "Angle-Resolved OCT" in which depth scans (A-lines) are obtained simultaneously from a broad range of backscattering angles. We demonstrated that high levels of speckle reduction can be achieved by averaging the magnitudes of A-lines corresponding to the same transverse locations. With both experimental and analytic approaches, we demonstrated that this averaging method does not lead to a substantial loss in spatial resolution. We developed two different imaging systems for performing Angle-Resolved OCT. With the first system, angular data was acquired simultaneously; with the second, it was acquired sequentially. The first system had superior speckle-reduction capabilities but image quality degraded significantly with small sample movements. The second system allowed for in vivo imaging, as demonstrated with Resolved OCT systems, the speckle-reduced images showed hitherto unprecedented delineation of tissue microstructure.
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