東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Functional neuroanatomy during langu...

Serafini, Sandra.

Linked to FindBook

Google Book

Amazon

博客來

Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task./
Author:	Serafini, Sandra.
Description:	345 p.
Notes:	Chair: Patricia K. Kuhl.
Contained By:	Dissertation Abstracts International63-05B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3053554
ISBN:	9780493683416

Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task.
Serafini, Sandra.

Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task. - 345 p.

Chair: Patricia K. Kuhl.

Thesis (Ph.D.)--University of Washington, 2002.

This study examines the correspondence of functional language maps using Cortical Stimulation Mapping (CSM), functional MRI (fMRI), Proton Echo-Planar Spectroscopic Imaging (PEPSI), and source localizations from Event-Related Potentials (ERP) during a visual object naming task in two patients undergoing treatment for intractable epilepsy. The spatial relationship between fMRI/PEPSI peak activations and CSM language sites was quantitatively analyzed, indicating minimal correspondence across these techniques. Qualitatively, areas of activation that were common across imaging techniques corresponded well with sites of naming disruption in the anterior superior temporal gyrus and posterior middle temporal gyrus. One control subject participated in fMRI, PEPSI, and ERP sessions and is also examined. For all subjects, fMRI/PEPSI activations and ERP sources for N100 and N400 components were consistent with neuroanatomical areas described for visual object naming in the fMRI and PET literature. Areas most consistently activated across fMRI/PEPSI/ERP techniques were the middle temporal gyrus posteriorly and the superior frontal gyrus and insula anteriorly. ERP scalp distributions for the N100 component across subjects were consistently prominent over anterior sites, while prominent amplitudes for the N400 component varied across subjects in posterior, centro-temporal, and anterior sites. Sources for the N100 component were also consistent across subjects in posterior areas, likely reflecting visual processing, while sources for the N400 component varied across subjects in frontal, temporal, and parietal areas, possibly reflecting not only semantic, but phonological processing as well. Concurrent anterior and posterior fMRI activations appear to be functionally distinguishable based on the ERP source data, again with posterior activations reflecting lower-level visual processing and anterior activations reflecting semantic or phonological processing. Implications for the functional role of specific anatomical structures (e.g. middle temporal gyrus) based on these correspondences are discussed. Theoretical issues pertaining to the physiological mechanisms of CSM disruption, fMRI-BOLD activations, lactate metabolism, and ERP source localizations are also examined to account for matches and mismatches across techniques.

ISBN: 9780493683416Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task.
LDR:03333nam 2200289 a 45 001 958609
005 20110704
008 110704s2002 ||||||||||||||||| ||eng d
020 $a 9780493683416
035 $a (UMI)AAI3053554
035 $a AAI3053554
040 $a UMI $c UMI
100 1 $a Serafini, Sandra. $3 1282067
245 1 0 $a Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task.
300 $a 345 p.
500 $a Chair: Patricia K. Kuhl.
500 $a Source: Dissertation Abstracts International, Volume: 63-05, Section: B, page: 2644.
502 $a Thesis (Ph.D.)--University of Washington, 2002.
520 $a This study examines the correspondence of functional language maps using Cortical Stimulation Mapping (CSM), functional MRI (fMRI), Proton Echo-Planar Spectroscopic Imaging (PEPSI), and source localizations from Event-Related Potentials (ERP) during a visual object naming task in two patients undergoing treatment for intractable epilepsy. The spatial relationship between fMRI/PEPSI peak activations and CSM language sites was quantitatively analyzed, indicating minimal correspondence across these techniques. Qualitatively, areas of activation that were common across imaging techniques corresponded well with sites of naming disruption in the anterior superior temporal gyrus and posterior middle temporal gyrus. One control subject participated in fMRI, PEPSI, and ERP sessions and is also examined. For all subjects, fMRI/PEPSI activations and ERP sources for N100 and N400 components were consistent with neuroanatomical areas described for visual object naming in the fMRI and PET literature. Areas most consistently activated across fMRI/PEPSI/ERP techniques were the middle temporal gyrus posteriorly and the superior frontal gyrus and insula anteriorly. ERP scalp distributions for the N100 component across subjects were consistently prominent over anterior sites, while prominent amplitudes for the N400 component varied across subjects in posterior, centro-temporal, and anterior sites. Sources for the N100 component were also consistent across subjects in posterior areas, likely reflecting visual processing, while sources for the N400 component varied across subjects in frontal, temporal, and parietal areas, possibly reflecting not only semantic, but phonological processing as well. Concurrent anterior and posterior fMRI activations appear to be functionally distinguishable based on the ERP source data, again with posterior activations reflecting lower-level visual processing and anterior activations reflecting semantic or phonological processing. Implications for the functional role of specific anatomical structures (e.g. middle temporal gyrus) based on these correspondences are discussed. Theoretical issues pertaining to the physiological mechanisms of CSM disruption, fMRI-BOLD activations, lactate metabolism, and ERP source localizations are also examined to account for matches and mismatches across techniques.
590 $a School code: 0250.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Cognitive. $3 1017810
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0317
690 $a 0349
690 $a 0633
710 2 $a University of Washington. $3 545923
773 0 $t Dissertation Abstracts International $g 63-05B.
790 $a 0250
790 1 0 $a Kuhl, Patricia K., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3053554