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Investigation of a potential macromo...

Wang, Jianxin Steven.

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Investigation of a potential macromolecular MRI contrast agent prepared from PPI (G = 2, polypropyleneimine, generation 2) dendrimer bifunctional chelates.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Investigation of a potential macromolecular MRI contrast agent prepared from PPI (G = 2, polypropyleneimine, generation 2) dendrimer bifunctional chelates./
作者:	Wang, Jianxin Steven.
面頁冊數:	91 p.
附註:	Adviser: Erik C. Wiener.
Contained By:	Dissertation Abstracts International64-03B.
標題:	Chemistry, Radiation. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3086210
ISBN:	9780496340163

Investigation of a potential macromolecular MRI contrast agent prepared from PPI (G = 2, polypropyleneimine, generation 2) dendrimer bifunctional chelates.
Wang, Jianxin Steven.

Investigation of a potential macromolecular MRI contrast agent prepared from PPI (G = 2, polypropyleneimine, generation 2) dendrimer bifunctional chelates. - 91 p.

Adviser: Erik C. Wiener.

Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003.

A small animal whole body counter was designed and constructed to allow us to monitor biodistribution and kinetic mechanisms using a radioisotope labeled complex.

ISBN: 9780496340163Subjects--Topical Terms:

1017804
Chemistry, Radiation.

Investigation of a potential macromolecular MRI contrast agent prepared from PPI (G = 2, polypropyleneimine, generation 2) dendrimer bifunctional chelates.
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100 1 $a Wang, Jianxin Steven. $3 1281887
245 1 0 $a Investigation of a potential macromolecular MRI contrast agent prepared from PPI (G = 2, polypropyleneimine, generation 2) dendrimer bifunctional chelates.
300 $a 91 p.
500 $a Adviser: Erik C. Wiener.
500 $a Source: Dissertation Abstracts International, Volume: 64-03, Section: B, page: 1465.
502 $a Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2003.
520 $a A small animal whole body counter was designed and constructed to allow us to monitor biodistribution and kinetic mechanisms using a radioisotope labeled complex.
520 $a Magnetic resonance imaging of this complex resulted in a 52% contrast enhancement in the rat kidney following the agents' administration in vivo.
520 $a The procedures of metal labeling, separation and purification have been established from this work.
520 $a The long-term objective is to develop magnetic resonance (MR) contrast agents that actively and passively target tumors for diagnosis and therapy. Many diagnostic imaging techniques for cancer lack specificity. A dendrimer based magnetic resonance imaging contrast agent has been developed with large proton relaxation enhancements and high molecular relaxivities.
520 $a A new type of linear dendrimer based MRI contrast agent that is built from the polypropyleneimine and polyamidoamine dendrimers in which free amines have been conjugated to the chelate DTPA, which further formed the complex with Gadolinium (Gd) was studied. The specific research goals were to test the hypothesis that a linear chelate with macromolecular agents can be used in vitro and in vivo. This work successfully examined the adequacy and viability of the application for this agent in vitro and in vivo.
520 $a A biodistribution study has been performed using radioisotope induced organ/tissue counting and gamma camera imaging. The ratio of percentage of injected dose per gram organ/tissue for kidney and liver is 3.71 from whole body counter and 3.77 from the gamma camera. The results suggested that retention of Gd (III) is too high and a more kinetically stable chelate should be developed.
520 $a The pharmacokinetic was evaluated in the whole animal model with the whole body clearance, and a kinetics model was developed. The pharmacokinetic results showed a bi-exponential decay in the animal model with two component excretion constants 1.43e(-5) and 0.0038511, which give half-lives of 3 hours and 33.6 days, respectively.
590 $a School code: 0090.
650 4 $a Chemistry, Radiation. $3 1017804
650 4 $a Engineering, Nuclear. $3 1043651
650 4 $a Health Sciences, Radiology. $3 1019076
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710 2 0 $a University of Illinois at Urbana-Champaign. $3 626646
773 0 $t Dissertation Abstracts International $g 64-03B.
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790 1 0 $a Wiener, Erik C., $e advisor
791 $a Ph.D.
792 $a 2003
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