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Effects of menopause and menopausal ...

Yim, So Fan.

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Effects of menopause and menopausal hormone therapy on vascular reactivity in Hong Kong Chinese women.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of menopause and menopausal hormone therapy on vascular reactivity in Hong Kong Chinese women./
Author:	Yim, So Fan.
Description:	194 p.
Notes:	Adviser: C. J. Haines.
Contained By:	Dissertation Abstracts International68-09B.
Subject:	Health Sciences, Obstetrics and Gynecology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3281440
ISBN:	9780549230823

Effects of menopause and menopausal hormone therapy on vascular reactivity in Hong Kong Chinese women.
Yim, So Fan.

Effects of menopause and menopausal hormone therapy on vascular reactivity in Hong Kong Chinese women. - 194 p.

Adviser: C. J. Haines.

Thesis (M.D.)--The Chinese University of Hong Kong (Hong Kong), 2006.

Hypothesis 3. That menopausal hormone therapy using oestrogen combined with progestogen given in either continuous (3a) or cyclical (3b) regimens improves arterial relaxation in postmenopausal Hong Kong Chinese women.

ISBN: 9780549230823Subjects--Topical Terms:

1020690
Health Sciences, Obstetrics and Gynecology.

Effects of menopause and menopausal hormone therapy on vascular reactivity in Hong Kong Chinese women.
LDR:05794nam 2200385 a 45 001 947951
005 20110524
008 110524s2006 ||||||||||||||||| ||eng d
020 $a 9780549230823
035 $a (UMI)AAI3281440
035 $a AAI3281440
040 $a UMI $c UMI
100 1 $a Yim, So Fan. $3 1271415
245 1 0 $a Effects of menopause and menopausal hormone therapy on vascular reactivity in Hong Kong Chinese women.
300 $a 194 p.
500 $a Adviser: C. J. Haines.
500 $a Source: Dissertation Abstracts International, Volume: 68-09, Section: B, page: 5873.
502 $a Thesis (M.D.)--The Chinese University of Hong Kong (Hong Kong), 2006.
520 $a Hypothesis 3. That menopausal hormone therapy using oestrogen combined with progestogen given in either continuous (3a) or cyclical (3b) regimens improves arterial relaxation in postmenopausal Hong Kong Chinese women.
520 $a Hypothesis 4. That menopausal hormone therapy using combined oestrogen with progestogen improves arterial relaxation in postmenopausal Hong Kong Chinese women with established coronary heart disease.
520 $a This thesis tested the following hypotheses: Hypothesis 1. That vascular reactivity decreases after the menopause as shown in premenopausal Hong Kong Chinese women with either a surgical (1a) or a medically induced (1b) menopause.
520 $a This thesis will examine the effects of menopause and menopausal HT on arterial reactivity which is an indirect measurement of vascular function. Previous studies have shown that oestrogen is a potent coronary artery vasodilator, and this effect may be mediated via both endothelium-dependent and endothelium-independent mechanisms. One method of assessing vascular reactivity is to use ultrasound measurement of changes in brachial artery diameter in response to certain stimuli. Using this technique, changes in both endothelium-dependent and endothelium-independent vasodilatation can be measured. Increased rather than decreased arterial relaxation after stimulus can be viewed as a favourable response.
520 $a Conclusion 1. The results of the research partly supported hypothesis 1a. There was a significant reduction in both endothelium-dependent arterial relaxation following a surgical menopause. The results of the research partly supported hypothesis 1b. There was a significant reduction in endothelium-dependent arterial relaxation but no significant effect on endothelium-independent arterial relaxation.
520 $a Hypothesis 2. This hypothesis examined three different types of commonly used menopausal HT. That unopposed oestrogen (2a), oestrogen combined with a progestogen (2b and 2d) or a synthetic steriod that has oestrogenic, progestogenic as well as androgenic activity (tibolone, 2c), reverse the reduction in arterial relaxation following menopause in Hong Kong Chinese women.
520 $a Conclusion 2. The results of the research partly supported hypothesis 2a. The addition of unopposed oestrogen significantly improved endothelium-dependent but not endothelium-independent arterial relaxation. The results of the research supported hypothesis 2b. The addition of oestradiol combined with progestogen (norethisterone acetate) reversed the reduction in arterial relaxation caused by a surgical menopause. The results of the research partly supported hypothesis 2c. The addition of tibolone reversed the reduction endothelium-dependent but not endothelium-independent arterial relaxation. The results of the research partly supported hypothesis 2d. The addition of oestradiol combined with a progestogen (norethisterone acetate) reversed the reduction in endothelium-dependent but not endothelium-independent arterial relaxation.
520 $a Conclusion 3. The results of the research partly supported hypothesis 3a. Endothelium-dependent arterial relaxation but no endothelium-independent arterial relaxation was improved after the addition of menopausal hormone therapy using oestrogen combined with a progestogen in a continuous manner. The results of the research did not support hypothesis 3b. Neither endothelium-dependent arterial relaxation nor the endothelium-independent arterial relaxation was improved by cyclical menopausal HT.
520 $a Conclusion 4. The results of the research did not support hypothesis 4. The addition of menopausal hormone therapy using combined oestrogen with progestogen did not improve arterial relaxation in postmenopausal women with established coronary heart disease.
520 $a Summary. Menopause results in a reduction in arterial relaxation. However, GnRHa temporarily induced menopause in young women, the endothelium-independent vasodilatation was not impaired. This difference can be partly explained by the difference in age as vascular reactivity is age dependent. Secondly, GnRHa works with an initial phase of increase in oestrogen production resulting in a shorter duration of hypo-oestrogenism resulting in the lack of impairment on endothelium-independent vasodilatation.
520 $a Menopausal HT can in general at least partially reverse changes in arterial relaxation in postmenopausal women. Different types of menopausal HT exhibit different effects on arterial relaxation. In healthy vessels, menopause HT mainly reverses the endothelium-dependent vascular effect, but it remains unclear how menopausal HT affects the endothelium-independent vascular effect. However, with established coronary heart disease, menopausal HT cannot reverse the changes in vascular reactivity.
590 $a School code: 1307.
650 4 $a Health Sciences, Obstetrics and Gynecology. $3 1020690
690 $a 0380
710 2 $a The Chinese University of Hong Kong (Hong Kong). $3 1017547
773 0 $t Dissertation Abstracts International $g 68-09B.
790 $a 1307
790 1 0 $a Haines, C. J., $e advisor
791 $a M.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3281440