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Characterization of PLLA:PEG membran...

Swaminathan, Vijaya.

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Characterization of PLLA:PEG membranes for dermal regeneration.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Characterization of PLLA:PEG membranes for dermal regeneration./
作者:	Swaminathan, Vijaya.
面頁冊數:	114 p.
附註:	Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: .
Contained By:	Dissertation Abstracts International69-06B.
標題:	Chemistry, Pharmaceutical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3319210
ISBN:	9780549693130

Characterization of PLLA:PEG membranes for dermal regeneration.
Swaminathan, Vijaya.

Characterization of PLLA:PEG membranes for dermal regeneration. - 114 p.

Source: Dissertation Abstracts International, Volume: 69-06, Section: B, page: .

Thesis (Ph.D.)--University of the Sciences in Philadelphia, 2008.

Poly-l-lactic acid (PLLA) is an aliphatic biodegradable polyester that has been widely investigated for drug delivery and tissue engineering applications. PLLA is a highly hydrophobic polymer making it impermeable and its high glass transition temperature renders it brittle at room temperature. In order to improve these properties, hydrophilic polyethylene glycol (PEG) was blended with PLLA. Initially, the overall goal was to investigate the feasibility of PLLA:PEG capsules as a reservoir delivery system for immunoisolation/cell encapsulation purposes. The two specific aims were to fabricate gelatin microcarriers and test their suitability as substrates for betaTC-6 cells, and fabricate PLLA:PEG reservoir capsules to encapsulate the cells. The capsules were tested for permeability to FITC-dextrans of different molecular weights. The lack of cell growth, the absence of both selective permeability and membrane controlled release from the reservoir capsules, led us to investigate alternative applications of PLLA:PEG membranes.

ISBN: 9780549693130Subjects--Topical Terms:

550957
Chemistry, Pharmaceutical.

Characterization of PLLA:PEG membranes for dermal regeneration.
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520 $a Poly-l-lactic acid (PLLA) is an aliphatic biodegradable polyester that has been widely investigated for drug delivery and tissue engineering applications. PLLA is a highly hydrophobic polymer making it impermeable and its high glass transition temperature renders it brittle at room temperature. In order to improve these properties, hydrophilic polyethylene glycol (PEG) was blended with PLLA. Initially, the overall goal was to investigate the feasibility of PLLA:PEG capsules as a reservoir delivery system for immunoisolation/cell encapsulation purposes. The two specific aims were to fabricate gelatin microcarriers and test their suitability as substrates for betaTC-6 cells, and fabricate PLLA:PEG reservoir capsules to encapsulate the cells. The capsules were tested for permeability to FITC-dextrans of different molecular weights. The lack of cell growth, the absence of both selective permeability and membrane controlled release from the reservoir capsules, led us to investigate alternative applications of PLLA:PEG membranes.
520 $a The effect of PEG molecular weight and in vitro degradation on the physical properties of PLLA:PEG membranes was investigated. The membranes were thoroughly characterized for their morphological, thermal, mechanical and permeability properties. PLLA:PEG membranes showed dual surface morphology with a porous and a non-porous/dense surface. They were mechanically strong and possessed high barrier efficacy; retaining mechanical properties for up to 6 weeks in vitro. The membranes also exhibited strength comparable to standard cellulose acetate membranes. PLLA:PEG membranes were tested for their ability to support attachment and growth of human dermal fibroblasts. All the membranes supported attachment of HDFa cells, but only PLLA:PEG 1450 and PLLA:PEG 8000 membranes showed significant proliferation. Thus after investigation of cellular activity on these membranes, PLLA:PEG 1450 and 8000 membranes could have potential for applications as skin substitutes for dermal regeneration.
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