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Analytical and numerical nanoindenta...

Gupta, Shikha.

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Analytical and numerical nanoindentation studies of compliant biomaterials and soft tissues.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Analytical and numerical nanoindentation studies of compliant biomaterials and soft tissues./
作者:	Gupta, Shikha.
面頁冊數:	270 p.
附註:	Adviser: Lisa A. Pruitt.
Contained By:	Dissertation Abstracts International69-09B.
標題:	Engineering, Biomedical. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3331621
ISBN:	9780549834427

Analytical and numerical nanoindentation studies of compliant biomaterials and soft tissues.
Gupta, Shikha.

Analytical and numerical nanoindentation studies of compliant biomaterials and soft tissues. - 270 p.

Adviser: Lisa A. Pruitt.

Thesis (Ph.D.)--University of California, Berkeley, 2008.

There is presently a dearth of knowledge regarding orthopaedic tissue mechanics, and its role in aging, disease progression, and remodeling. Mechanical characterization of tissues from different in-vivo, ex-vivo, and in-vitro experimental models remains a formidable challenge. The tissues in these models are heterogeneous, nonlinear, hydrated, viscoelastic, and usually present in small volumes. While these attributes still permit the biochemical characterization of the tissues, they preclude the use of global mechanical testing protocols for characterizing mechanical properties. Since orthopaedic tissues are load-bearing, characterization of biochemical properties alone is insufficient for assessing the healthy and functionality of the tissues.

ISBN: 9780549834427Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Analytical and numerical nanoindentation studies of compliant biomaterials and soft tissues.
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245 1 0 $a Analytical and numerical nanoindentation studies of compliant biomaterials and soft tissues.
300 $a 270 p.
500 $a Adviser: Lisa A. Pruitt.
500 $a Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5571.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2008.
520 $a There is presently a dearth of knowledge regarding orthopaedic tissue mechanics, and its role in aging, disease progression, and remodeling. Mechanical characterization of tissues from different in-vivo, ex-vivo, and in-vitro experimental models remains a formidable challenge. The tissues in these models are heterogeneous, nonlinear, hydrated, viscoelastic, and usually present in small volumes. While these attributes still permit the biochemical characterization of the tissues, they preclude the use of global mechanical testing protocols for characterizing mechanical properties. Since orthopaedic tissues are load-bearing, characterization of biochemical properties alone is insufficient for assessing the healthy and functionality of the tissues.
520 $a The advent of nanoindentation has provided a method for determining time-dependent mechanical properties on a size-scale compatible with tissue dimensions in controlled, physiological environments. However, nanoindentation theory and instrumentation were developed for hard, elastic-plastic materials and limited nanoindentation work has been performed in compliant biomaterials. Though most nanoindentation studies of soft biomaterials have adopted analytical and experimental methods originally derived for elastic-plastic materials, use of these methods has not been validated for compliant materials. The goal of the thesis was to conduct a systematic evaluation of the capabilities and limitations of nanoindentation in characterizing soft biomaterials.
520 $a Nanoindentation experiments were conducted on polydimethylsiloxane (PDMS), agarose gels, and porcine costal cartilage (PCC). These experiments showed that nanoindentation is capable of differentiating between soft biomaterials that have differences in stiffness of less than a few hundred kilopascals, that the equilibrium elastic modulus values determined from nanoindentation are consistent over a range of different experimental testing conditions, and that the material properties determined from nanoindentation are comparable to those determined from conventional methods, such as unconfined compression. Experiments with PDMS also highlighted the importance of accounting for the work of adhesion between the indenter tip and substrate when analyzing nanoindentation data, while PCC studies elucidated the effects of surface preparation methods, such as microtoming, on soft tissue indentation. Finally, a novel method for coupling nanoindentation with finite element simulations was developed to determine material properties from physiological relevant constitutive models, including fiber-reinforced poroelastic models.
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790 1 0 $a Pruitt, Lisa A., $e advisor
791 $a Ph.D.
792 $a 2008
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