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The role of transforming growth fact...

Dahly-Vernon, Annette Jane.

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The role of transforming growth factor beta (TGF-beta) in hypertension and renal disease in Dahl salt-sensitive rats.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of transforming growth factor beta (TGF-beta) in hypertension and renal disease in Dahl salt-sensitive rats./
Author:	Dahly-Vernon, Annette Jane.
Description:	207 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3495.
Contained By:	Dissertation Abstracts International66-07B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3181138
ISBN:	9780542217302

The role of transforming growth factor beta (TGF-beta) in hypertension and renal disease in Dahl salt-sensitive rats.
Dahly-Vernon, Annette Jane.

The role of transforming growth factor beta (TGF-beta) in hypertension and renal disease in Dahl salt-sensitive rats. - 207 p.

Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3495.

Thesis (Ph.D.)--The Medical College of Wisconsin, 2005.

Previous studies have indicated that transforming growth factor-beta (TGF-beta) is upregulated in diabetes and hypertension. Elevated expression of TGF-beta has been postulated to contribute to end organ damage in the kidney, heart, and vasculature in patients with diabetes and hypertension. Several studies have shown that a high salt diet stimulates the production of TGF-beta and increases the levels of TGF-beta1, beta2, and beta3 in the kidney. However, previous studies have not examined the contribution of TGF-beta to the development of hypertension-induced renal disease in Dahl S rats. Part of the problem has been due to the lack of inhibitors or molecular approaches to effectively block this pathway in vivo. This dissertation examined the hypothesis that the expression of TGF-beta in the kidney increases during the development of hypertension in Dahl saltsensitive (Dahl SSJr) rats fed a high salt diet and that TGF-beta contributes to proteinuria by increasing permeability of podocytes. This promotes renal fibrosis in the glomerulus and vasa recta capillaries.

ISBN: 9780542217302Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The role of transforming growth factor beta (TGF-beta) in hypertension and renal disease in Dahl salt-sensitive rats.
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005 20110523
008 110523s2005 ||||||||||||||||| ||eng d
020 $a 9780542217302
035 $a (UMI)AAI3181138
035 $a AAI3181138
040 $a UMI $c UMI
100 1 $a Dahly-Vernon, Annette Jane. $3 1270418
245 1 4 $a The role of transforming growth factor beta (TGF-beta) in hypertension and renal disease in Dahl salt-sensitive rats.
300 $a 207 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3495.
502 $a Thesis (Ph.D.)--The Medical College of Wisconsin, 2005.
520 $a Previous studies have indicated that transforming growth factor-beta (TGF-beta) is upregulated in diabetes and hypertension. Elevated expression of TGF-beta has been postulated to contribute to end organ damage in the kidney, heart, and vasculature in patients with diabetes and hypertension. Several studies have shown that a high salt diet stimulates the production of TGF-beta and increases the levels of TGF-beta1, beta2, and beta3 in the kidney. However, previous studies have not examined the contribution of TGF-beta to the development of hypertension-induced renal disease in Dahl S rats. Part of the problem has been due to the lack of inhibitors or molecular approaches to effectively block this pathway in vivo. This dissertation examined the hypothesis that the expression of TGF-beta in the kidney increases during the development of hypertension in Dahl saltsensitive (Dahl SSJr) rats fed a high salt diet and that TGF-beta contributes to proteinuria by increasing permeability of podocytes. This promotes renal fibrosis in the glomerulus and vasa recta capillaries.
520 $a Specific aims that are as follows: (1) To study the role of TGF-beta in the pathogenesis of renal disease in Dahl S rats by chronically blocking the effects of TGF-beta with an neutralizing antibody (Ab, 1D11) that inactivates TGF-beta1, 2, and 3. (2) To determine whether a sexual dimorphism exists in the development of hypertension and renal disease in Dahl S rats and the role of TGF-beta in mediating the differences in responses seen in male and female rats. (3) To compare the ability of chronic blockade of TGF-beta to prevent renal damage during the development of hypertension versus the effects of antihypertensive agents. (4) To examine the role of TGF-beta in altering the glomerular permeability to albumin during the development of hypertension in Dahl S rats and whether TGF-beta acts in part by inhibiting the glomerular production of 20-hydroxyeicosatetraenoic acid (20-HETE).
520 $a In aim 1, we examined the role of TGF-beta in the development of hypertension, glomerulosclerosis, proteinuria, and tubulointerstitial renal disease male Dahl S rats fed a high salt diet for three weeks. The rats received i.p. injections of a control or an anti-TGF-beta Ab every other day for two weeks. (Abstract shortened by UMI.)
590 $a School code: 0495.
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0433
710 2 $a The Medical College of Wisconsin. $3 1021876
773 0 $t Dissertation Abstracts International $g 66-07B.
790 $a 0495
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3181138