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Development of ocular drug delivery ...

Haesslein, Andrea.

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Development of ocular drug delivery systems using biodegradable polymers.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Development of ocular drug delivery systems using biodegradable polymers./
Author:	Haesslein, Andrea.
Description:	152 p.
Notes:	Adviser: Antonios G. Mikos.
Contained By:	Masters Abstracts International45-04.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441824

Development of ocular drug delivery systems using biodegradable polymers.
Haesslein, Andrea.

Development of ocular drug delivery systems using biodegradable polymers. - 152 p.

Adviser: Antonios G. Mikos.

Thesis (M.S.)--Rice University, 2007.

We found that prefabricated, photo-crosslinked PPF/PNVP matrices represent suitable, controllable release systems for different drugs. Furthermore, coaxial electrospinning is a promising technique to generate scaffolds for drug delivery.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Development of ocular drug delivery systems using biodegradable polymers.
LDR:01869nam 2200277 a 45 001 946125
005 20110523
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035 $a (UMI)AAI1441824
035 $a AAI1441824
040 $a UMI $c UMI
100 1 $a Haesslein, Andrea. $3 1269536
245 1 0 $a Development of ocular drug delivery systems using biodegradable polymers.
300 $a 152 p.
500 $a Adviser: Antonios G. Mikos.
500 $a Source: Masters Abstracts International, Volume: 45-04, page: 2022.
502 $a Thesis (M.S.)--Rice University, 2007.
520 $a We found that prefabricated, photo-crosslinked PPF/PNVP matrices represent suitable, controllable release systems for different drugs. Furthermore, coaxial electrospinning is a promising technique to generate scaffolds for drug delivery.
520 $a The delivery of drugs plays an important role in the treatment of ocular diseases. In this thesis, biocompatible, biodegradable materials such as poly(propylene fumarate) (PPF) and poly(lactic-co-glycolic) (PLGA) were used to prepare delivery systems. PPF together with N-vinyl pyrrolidone (NVP) was photo-crosslinked to generate monolithic polymer rods, which were loaded with either acetazolamide (AZ), dichlorphenamide (DP) or timolol maleate (TM). The release kinetics and structural properties were determined as well as the in vivo degradation. Further studies were performed to examine the influence of PPF molecular weight and the ratio of PPF/PNVP on the release kinetics. In addition, a coaxial electrospinning setup was developed to fabricate PLGA fiber networks as a delivery system.
590 $a School code: 0187.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Ophthalmology. $3 1019445
690 $a 0381
690 $a 0541
710 2 $a Rice University. $3 960124
773 0 $t Masters Abstracts International $g 45-04.
790 $a 0187
790 1 0 $a Mikos, Antonios G., $e advisor
791 $a M.S.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1441824