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The role of T-bet and eomesodermin i...

Intlekofer, Andrew Michael.

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The role of T-bet and eomesodermin in effector and memory CD8+ T cell differentiation.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The role of T-bet and eomesodermin in effector and memory CD8+ T cell differentiation./
作者:	Intlekofer, Andrew Michael.
面頁冊數:	146 p.
附註:	Adviser: Steven L. Reiner.
Contained By:	Dissertation Abstracts International68-11B.
標題:	Biology, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3292034
ISBN:	9780549346036

The role of T-bet and eomesodermin in effector and memory CD8+ T cell differentiation.
Intlekofer, Andrew Michael.

The role of T-bet and eomesodermin in effector and memory CD8+ T cell differentiation. - 146 p.

Adviser: Steven L. Reiner.

Thesis (Ph.D.)--University of Pennsylvania, 2007.

We sought to investigate the role of the T-box transcription factors, T-bet and eomesodermin (Eomes), in regulating the differentiation, homeostasis, and function of effector and memory CD8+ T cells. We found that T-bet and Eomes cooperatively control expression of genes required for cytotoxic effector function. CD8+ T cells deficient for both T-bet and Eomes fail to support host defense against lymphocytic choriomeningitis virus (LCMV) infection, lack the ability to kill target cells or secrete Type 1 cytokines, and undergo anomalous Type 17 differentiation. Upon infection with LCMV, mice with T cells lacking both T-bet and Eomes develop a CD8 + T cell-dependent, progressive wasting disease characterized by multi-organ neutrophilic inflammation. In addition to their essential role in effector differentiation, we found that T-bet and Eomes control the homeostasis of cytotoxic immune cells, as mice with compound mutations in the genes encoding T-bet and Eomes are nearly devoid of immune lineages dependent on interleukin 15 (IL-15), including memory CD8+ T cells. We determined that T-bet and Eomes are responsible for inducing enhanced expression of CD122, the receptor specifying IL-15 responsiveness. An examination of the differential contributions of T-bet and Eomes to CD8+ T cell differentiation revealed that T-bet preferentially drives terminal differentiation of effector-like cells at the expense of self-renewing memory cells. Thus, T-bet and Eomes appear to independently and semi-redundantly induce the genetic program necessary for Type 1 CD8+ T cell differentiation, whereas their unique functions may differentially contribute to acute versus long-term defense against intracellular pathogens.

ISBN: 9780549346036Subjects--Topical Terms:

1018625
Biology, General.

The role of T-bet and eomesodermin in effector and memory CD8+ T cell differentiation.
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