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Balancing between immunity and toler...

Cools, Nathalie.

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Balancing between immunity and tolerance: Interplay between dendritic cells, effector T cells and regulatory T cells.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Balancing between immunity and tolerance: Interplay between dendritic cells, effector T cells and regulatory T cells./
作者:	Cools, Nathalie.
面頁冊數:	172 p.
附註:	Advisers: Zwi Berneman; Peter Ponsaerts; Viggo Van Tendeloo.
Contained By:	Dissertation Abstracts International68-08B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3279402
ISBN:	9780549203476

Balancing between immunity and tolerance: Interplay between dendritic cells, effector T cells and regulatory T cells.
Cools, Nathalie.

Balancing between immunity and tolerance: Interplay between dendritic cells, effector T cells and regulatory T cells. - 172 p.

Advisers: Zwi Berneman; Peter Ponsaerts; Viggo Van Tendeloo.

Thesis (Ph.D.)--Universiteit Antwerpen (Belgium), 2007.

In order to maintain the balance between immunity and tolerance, dendritic cells (DC), a highly specialised population of white blood cells, play an important role. The use of DC for the generation of anti-tumour immunity is currently a popular track for the development of cellular anti-tumour vaccines. Cervical cancer is caused by infection with the human papillomavirus (HPV). In this study, we developed and validated a DC-based immunotherapy for stimulation of cellular immunity against HPV type 16 (HPV-16). We can detect a tumour antigen-specific cellular immune response in 5/5 healthy volunteers. However, the cultivation protocol was rather time-consuming and suboptimal as multiple rounds of in vitro stimulation with tumour antigen-loaded DC were necessary. Moreover, stimulation of tumour antigen-specific T-cells was only possible using purified CD8+ T-cells. These obstacles suggested the influence of other (T) cell populations capable of suppressing anti-tumour immunity. Therefore, research towards a better understanding of the cellular interactions as well as the mechanisms involved in immunity as well as tolerance, is warranted.

ISBN: 9780549203476Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Balancing between immunity and tolerance: Interplay between dendritic cells, effector T cells and regulatory T cells.
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245 1 0 $a Balancing between immunity and tolerance: Interplay between dendritic cells, effector T cells and regulatory T cells.
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500 $a Source: Dissertation Abstracts International, Volume: 68-08, Section: B, page: 5120.
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520 $a In order to maintain the balance between immunity and tolerance, dendritic cells (DC), a highly specialised population of white blood cells, play an important role. The use of DC for the generation of anti-tumour immunity is currently a popular track for the development of cellular anti-tumour vaccines. Cervical cancer is caused by infection with the human papillomavirus (HPV). In this study, we developed and validated a DC-based immunotherapy for stimulation of cellular immunity against HPV type 16 (HPV-16). We can detect a tumour antigen-specific cellular immune response in 5/5 healthy volunteers. However, the cultivation protocol was rather time-consuming and suboptimal as multiple rounds of in vitro stimulation with tumour antigen-loaded DC were necessary. Moreover, stimulation of tumour antigen-specific T-cells was only possible using purified CD8+ T-cells. These obstacles suggested the influence of other (T) cell populations capable of suppressing anti-tumour immunity. Therefore, research towards a better understanding of the cellular interactions as well as the mechanisms involved in immunity as well as tolerance, is warranted.
520 $a A major role in controlling both immunity and tolerance is also attributed to regulatory T-cells (Treg). While Treg in normal conditions regulate ongoing immune responses and prevent immunity, imbalanced function of these Treg might lead to decreased immunity or autoimmunity. We demonstrated that in vitro culture of peripheral blood lymphocytes (PBL) with both immature and mature DC resulted in an increase in the number of Treg with an increased expression of immune suppressive cytokines. In addition, the suppressive capacity of this CD4+ T-cell population was transferable to already activated antigen-specific CD8+ T-cells when CD4+ T-cells were conditioned by immature DC and cytokine cocktail-matured DC, but not when CD4+ T-cells were conditioned by Toll-like receptor (TLR)3 ligand-matured DC.
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