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Vitamin E (tocotrienols) and prostat...

Muenyi, Christian Mbangha.

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Vitamin E (tocotrienols) and prostate cancer: A proteomics approach.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Vitamin E (tocotrienols) and prostate cancer: A proteomics approach./
作者:	Muenyi, Christian Mbangha.
面頁冊數:	72 p.
附註:	Adviser: William L. Stone.
Contained By:	Masters Abstracts International46-01.
標題:	Chemistry, Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1445290
ISBN:	9780549109082

Vitamin E (tocotrienols) and prostate cancer: A proteomics approach.
Muenyi, Christian Mbangha.

Vitamin E (tocotrienols) and prostate cancer: A proteomics approach. - 72 p.

Adviser: William L. Stone.

Thesis (M.S.)--East Tennessee State University, 2007.

Proteomics is the large scale study of proteins in cells or organisms. The purpose of this study was to characterize the proteomic alterations occurring in a prostate cancer (LNCaP) cell line after treatment with delta-tocotrienol (a form of vitamin E not very prevalent from most dietary sources). We found that both gamma- and delta-tocotrienols induced time and concentration dependent growth inhibition and programmed cell dead (apoptosis) in LNCaP cells. Secondly, we used two-dimensional gel electrophoresis (2-DE) to characterize changes in protein expression levels associated with this treatment. Our results show that a specific set of proteins are regulated at both early and late times following treatment with delta-tocotrienol and these proteins have been characterized by their apparent molecular weights and isoelectric points. The alteration observed at early time points are particularly interesting because these changes are likely to reflect the underlying molecular mechanisms for triggering cancer cell death.

ISBN: 9780549109082Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Vitamin E (tocotrienols) and prostate cancer: A proteomics approach.
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