東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The effect of conjugated linoleic ac...

Huot, Pedro Sathia Piseth.

FindBook

Google Book

Amazon

博客來

The effect of conjugated linoleic acid on caveolae lipid composition and protein localization in breast cancer cells.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The effect of conjugated linoleic acid on caveolae lipid composition and protein localization in breast cancer cells./
作者:	Huot, Pedro Sathia Piseth.
面頁冊數:	95 p.
附註:	Source: Masters Abstracts International, Volume: 45-06, page: 3137.
Contained By:	Masters Abstracts International45-06.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR27381
ISBN:	9780494273814

The effect of conjugated linoleic acid on caveolae lipid composition and protein localization in breast cancer cells.
Huot, Pedro Sathia Piseth.

The effect of conjugated linoleic acid on caveolae lipid composition and protein localization in breast cancer cells. - 95 p.

Source: Masters Abstracts International, Volume: 45-06, page: 3137.

Thesis (M.Sc.)--University of Toronto (Canada), 2007.

Mechanisms by which conjugated linoleic acid (CLA) inhibits cancer cell growth are poorly understood. Caveolae are specialized plasma membrane structures involved in recruiting and regulating signaling proteins. The objective of this study was to determine if CLA incorporates into caveolae, thereby altering the expression of caveolae resident proteins in MCF-7 and MCF-7/Cav-1 human breast cancer cells. Cells were treated with either bovine serum albumin-vehicle, a mixture of CLA isomers, or LA (100 muM). CLA significantly incorporated into caveolae phospholipids. Delta9cis,11trans-18:2 was the major isomer found in caveolae phospholipids suggesting that this isomer is responsible for the reduction in caveolin protein expression. Incorporation of CLA reduced expression of caveolin-1 in MCF-7 caveolae, but had no effect on H-Ras expression. No effects were observed in MCF-7/Cav-1 cells on caveolin-1 and H-Ras expression. Overall, these findings suggest a potential mechanism by which CLA modulates cellular signaling in breast cancer cells.

ISBN: 9780494273814Subjects--Topical Terms:

1017686
Biology, Cell.

The effect of conjugated linoleic acid on caveolae lipid composition and protein localization in breast cancer cells.
LDR:01893nam 2200265 a 45 001 941628
005 20110519
008 110519s2007 eng d
020 $a 9780494273814
035 $a (UMI)AAIMR27381
035 $a AAIMR27381
040 $a UMI $c UMI
100 1 $a Huot, Pedro Sathia Piseth. $3 1265725
245 1 4 $a The effect of conjugated linoleic acid on caveolae lipid composition and protein localization in breast cancer cells.
300 $a 95 p.
500 $a Source: Masters Abstracts International, Volume: 45-06, page: 3137.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2007.
520 $a Mechanisms by which conjugated linoleic acid (CLA) inhibits cancer cell growth are poorly understood. Caveolae are specialized plasma membrane structures involved in recruiting and regulating signaling proteins. The objective of this study was to determine if CLA incorporates into caveolae, thereby altering the expression of caveolae resident proteins in MCF-7 and MCF-7/Cav-1 human breast cancer cells. Cells were treated with either bovine serum albumin-vehicle, a mixture of CLA isomers, or LA (100 muM). CLA significantly incorporated into caveolae phospholipids. Delta9cis,11trans-18:2 was the major isomer found in caveolae phospholipids suggesting that this isomer is responsible for the reduction in caveolin protein expression. Incorporation of CLA reduced expression of caveolin-1 in MCF-7 caveolae, but had no effect on H-Ras expression. No effects were observed in MCF-7/Cav-1 cells on caveolin-1 and H-Ras expression. Overall, these findings suggest a potential mechanism by which CLA modulates cellular signaling in breast cancer cells.
590 $a School code: 0779.
650 4 $a Biology, Cell. $3 1017686
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0379
690 $a 0570
690 $a 0992
710 2 0 $a University of Toronto (Canada). $3 1017674
773 0 $t Masters Abstracts International $g 45-06.
790 $a 0779
791 $a M.Sc.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR27381