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Effects of STZ induced hyperglycemia...

University of New Hampshire.

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Effects of STZ induced hyperglycemia and hyperlipemia on PPARgamma and ABCA1 in a hamster model of atherogenesis.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Effects of STZ induced hyperglycemia and hyperlipemia on PPARgamma and ABCA1 in a hamster model of atherogenesis./
作者:	LaMarca, Craig.
面頁冊數:	99 p.
附註:	Adviser: Thomas Foxall.
Contained By:	Masters Abstracts International45-01.
標題:	Agriculture, Animal Pathology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1437632
ISBN:	9780542853067

Effects of STZ induced hyperglycemia and hyperlipemia on PPARgamma and ABCA1 in a hamster model of atherogenesis.
LaMarca, Craig.

Effects of STZ induced hyperglycemia and hyperlipemia on PPARgamma and ABCA1 in a hamster model of atherogenesis. - 99 p.

Adviser: Thomas Foxall.

Thesis (M.S.)--University of New Hampshire, 2006.

Diabetes mellitus accelerates atherogenesis, but the exact mechanisms involved are unknown. This study examined the effects of hyperglycemia on the inflammatory transcription factor peroxisome proliferator activated receptor gamma (PPARgamma), known to be involved in atherogenesis, and the ATP binding cassette A1 (ABCA1) protein that is a downstream product of PPARgamma. ABCA1 is a membrane bound transporter that is involved in reverse cholesterol transport via high density lipoprotein cholesterol (HDL-C). Hamsters were divided into two groups; hyperlipemic animals fed a high fat/high cholesterol control diet (C) and hyperlipemic/hyperglycemic animals that received the high fat diet and were administered streptozotocin. Half of the hamsters (23) in each group were sacrificed at 8 weeks and the other half at 24 weeks. (Abstract shortened by UMI.)

ISBN: 9780542853067Subjects--Topical Terms:

1021764
Agriculture, Animal Pathology.

Effects of STZ induced hyperglycemia and hyperlipemia on PPARgamma and ABCA1 in a hamster model of atherogenesis.
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