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Effects of lactic acid bacteria on t...

Simon, Maria Victoria Tejada.

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Effects of lactic acid bacteria on the immune system.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Effects of lactic acid bacteria on the immune system./
作者:	Simon, Maria Victoria Tejada.
面頁冊數:	244 p.
附註:	Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3144.
Contained By:	Dissertation Abstracts International59-07B.
標題:	Agriculture, Food Science and Technology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9839702
ISBN:	9780591934083

Effects of lactic acid bacteria on the immune system.
Simon, Maria Victoria Tejada.

Effects of lactic acid bacteria on the immune system. - 244 p.

Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3144.

Thesis (Ph.D.)--Michigan State University, 1998.

Lactic acid bacteria are essential for the fermentation of products such as cheese, buttermilk and yogurt. An increasing number of functional foods and pharmaceutical preparations are being promoted with health claims based on the potential probiotic characteristics of some of these bacteria and on their capacity for stimulating the host immune system. A possible mechanism for these effects is direct stimulation of the gastrointestinal immune response. The specific objectives of these studies were to evaluate the effects of in vivo, ex vivo, and in vitro exposure to viable, non-viable strains, and cell extracts of lactic acid bacteria (Lactobacillus acidophilus, L. bulgaricus, L. casei, L. gasseri, L. helveticus, L. reuteri, Streptococcus thermophilus and Bifidobacterium) on leukocyte function. In vivo studies showed that growth rate of mice as well as immunoglobulin levels were not affected by direct oral administration of lactic acid bacteria. Although basal cytokine mRNA expression in spleen and Peyer's patches was not affected by repeated oral lactic acid bacteria administration (in vivo), single exposures to certain bacteria altered subsequent mitogen induced cytokine and nitric oxide production by peritoneal cells (ex vivo). When mice were fed a fermented milk manufactured with starter cultures containing different species/strains of lactic acid bacteria for three weeks and after immunizing twice with 10 $\mu

ISBN: 9780591934083Subjects--Topical Terms:

1017813
Agriculture, Food Science and Technology.

Effects of lactic acid bacteria on the immune system.
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520 $a Lactic acid bacteria are essential for the fermentation of products such as cheese, buttermilk and yogurt. An increasing number of functional foods and pharmaceutical preparations are being promoted with health claims based on the potential probiotic characteristics of some of these bacteria and on their capacity for stimulating the host immune system. A possible mechanism for these effects is direct stimulation of the gastrointestinal immune response. The specific objectives of these studies were to evaluate the effects of in vivo, ex vivo, and in vitro exposure to viable, non-viable strains, and cell extracts of lactic acid bacteria (Lactobacillus acidophilus, L. bulgaricus, L. casei, L. gasseri, L. helveticus, L. reuteri, Streptococcus thermophilus and Bifidobacterium) on leukocyte function. In vivo studies showed that growth rate of mice as well as immunoglobulin levels were not affected by direct oral administration of lactic acid bacteria. Although basal cytokine mRNA expression in spleen and Peyer's patches was not affected by repeated oral lactic acid bacteria administration (in vivo), single exposures to certain bacteria altered subsequent mitogen induced cytokine and nitric oxide production by peritoneal cells (ex vivo). When mice were fed a fermented milk manufactured with starter cultures containing different species/strains of lactic acid bacteria for three weeks and after immunizing twice with 10 $\mu $g cholera toxin, those mice responded by producing specific intestinal and serum IgA-anti cholera toxin, isotype that was significantly increased in mice fed yogurts made with starters containing Lactobacillus bulgaricus and Streptococcus thermophilus (yogurt bacteria) supplemented with L. acidophilus and Bifidobacterium spp. These results suggested that lactic acid bacteria may alter immune function in a strain dependent manner. The effects of in vitro exposure to heat-killed cells, their cell walls, and their cytoplasmic extracts on proliferation, cytokine and intermediate production were examined in the RAW 264.7 macrophage cell line, spleen and Peyer's patch cells as well as in peritoneal cells from mice. Lactic acid bacteria as well as their cytoplasmic and cell wall fractions were able to stimulate cloned macrophages to produce very significant amounts of TNF-$\alpha$, IL-6 and nitric oxide. While similar effects were not noted in spleen and Peyer's patch cell cultures from mice, a pronounced enhancement in IL-6 production by peritoneal cells was observed when cultured with those extracts. The results suggested that as a group, the lactic acid bacteria are capable of stimulating macrophages and/or other immune cells to produce cytokines and nitric oxide.
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