東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Influence of liposomal encapsulation...

Imbert, Delphine.

FindBook

Google Book

Amazon

博客來

Influence of liposomal encapsulation on the penetration of model compounds through human skin in vitro.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Influence of liposomal encapsulation on the penetration of model compounds through human skin in vitro./
作者:	Imbert, Delphine.
面頁冊數:	155 p.
附註:	Chair: R. R. Wickett.
Contained By:	Dissertation Abstracts International57-01B.
標題:	Health Sciences, Pharmacy. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9614493

Influence of liposomal encapsulation on the penetration of model compounds through human skin in vitro.
Imbert, Delphine.

Influence of liposomal encapsulation on the penetration of model compounds through human skin in vitro. - 155 p.

Chair: R. R. Wickett.

Thesis (Ph.D.)--University of Cincinnati, 1995.

The influence of liposomal encapsulation on the penetration of all trans-retinoic acid (t-RA) and carboxyinulin (Carb-I) was investigated using in vitro diffusion experiments on human cadaver skin. Two claims typically associated with topical liposomes were evaluated; (1) liposomes can act as penetration enhancers and increase the flux of poorly-penetrating compounds through the stratum corneum (SC), and (2) liposomes can act as drug localizers and prevent encapsulated compounds in the viable epidermis from reaching the systemic circulation.Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Influence of liposomal encapsulation on the penetration of model compounds through human skin in vitro.
LDR:03727nam 2200301 a 45 001 940807
005 20110518
008 110518s1995 ||||||||||||||||| ||eng d
035 $a (UMI)AAI9614493
035 $a AAI9614493
040 $a UMI $c UMI
100 1 $a Imbert, Delphine. $3 1264935
245 1 0 $a Influence of liposomal encapsulation on the penetration of model compounds through human skin in vitro.
300 $a 155 p.
500 $a Chair: R. R. Wickett.
500 $a Source: Dissertation Abstracts International, Volume: 57-01, Section: B, page: 0264.
502 $a Thesis (Ph.D.)--University of Cincinnati, 1995.
520 $a The influence of liposomal encapsulation on the penetration of all trans-retinoic acid (t-RA) and carboxyinulin (Carb-I) was investigated using in vitro diffusion experiments on human cadaver skin. Two claims typically associated with topical liposomes were evaluated; (1) liposomes can act as penetration enhancers and increase the flux of poorly-penetrating compounds through the stratum corneum (SC), and (2) liposomes can act as drug localizers and prevent encapsulated compounds in the viable epidermis from reaching the systemic circulation.
520 $a Phospholipid liposomes were prepared by Bangham's film method and by reverse phase evaporation. Size distributions were determined by quasi-elastic light scattering or Fraunhofer diffraction, depending of the range studied. Typically, liposomes used in the t-RA study exhibited diameters under 200 nm whereas those used for Carb-I were large heterogeneous vesicles with diameters of 2-20 $\mu $m . Methods to determine and increase liposome encapsulation efficiency of large hydrophilic compounds were evaluated. The Ficoll$\sp\circler$ discontinuous density gradient method was found to be an excellent tool for separating free and encapsulated inulin from large-size liposome preparations.
520 $a Incorporation of t-RA into either simple phosphatidylcholine (PC) liposomes or a more complex 4-component system, or that of Carb-I in PC/cholesterol liposomes, did not increase their penetration rates across human SC relative to unencapsulated controls. In both cases, reducing liposome size did not have a significant effect. Similar penetration profiles were obtained whether Carb-I was simply mixed with empty liposomes or partly encapsulated ($\sim $4 0%) into them.
520 $a Under most of the conditions studied, liposomes also failed to significantly reduce the delivery rate of the model compounds across dermatomed human skin relative to that across SC. A contamination-free method developed to analyze radiomarker levels in dermis yielded similar conclusions; hence, there was no evidence for liposome-induced accumulation of either t-RA or Carb-I in the lower skin layers in these studies. Under one set of conditions (large, non-occluded dose), there was evidence to suggest accumulation of t-RA in the skin. However, although widely used by other investigators, these conditions do not correspond to a practical dose regimen for a topical skin care product.
520 $a The depth of liposome penetration was evaluated using skin preparations of increasing thickness. When detectable, the amount of liposome marker going through the SC was at least one order of magnitude lower than that of the encapsulated compound, ruling out the hypothesis that concomitant diffusion of encapsulated compound with bilayer fragments could take place much deeper than the first few layers of the SC.
590 $a School code: 0045.
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0572
710 2 $a University of Cincinnati. $3 960309
773 0 $t Dissertation Abstracts International $g 57-01B.
790 $a 0045
790 1 0 $a Wickett, R. R., $e advisor
791 $a Ph.D.
792 $a 1995
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9614493