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Multi-level regulation of cyclin D3 ...

Cooper, Anthony Byron.

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Multi-level regulation of cyclin D3 controls pre-B cell expansion.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Multi-level regulation of cyclin D3 controls pre-B cell expansion./
作者:	Cooper, Anthony Byron.
面頁冊數:	198 p.
附註:	Adviser: Marcus R. Clark.
Contained By:	Dissertation Abstracts International68-02B.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3252227

Multi-level regulation of cyclin D3 controls pre-B cell expansion.
Cooper, Anthony Byron.

Multi-level regulation of cyclin D3 controls pre-B cell expansion. - 198 p.

Adviser: Marcus R. Clark.

Thesis (Ph.D.)--The University of Chicago, 2007.

During hematopoiesis, stem cell proliferation is dependent upon expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Analysis of Ccnd1-/-, Ccnd2-/-, Ccnd3-/- and Ccnd2-/-Ccnd3-/- mice revealed that cyclin D3 is uniquely required for the proliferative expansion of pre-B cells. Transcription of Ccnd3 is activated before the pro-B stage of development in a process dependent on expression of the common gamma chain of cytokine receptors. In contrast, expression of the pre-BCR and the activation of downstream signaling pathways involving Src and PI3K, but not BLNK, prevent proteasome-mediated cyclin D3 degradation. Additionally signaling through the IL-7 receptor regulates cyclin D3 expression via a mechanism independent of protein stability or transcription, possibly through translational regulation. Cyclin D3 plays a key role in B cell development by integrating cytokine and pre-BCR dependent signals at the appropriate developmental stage in order to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.Subjects--Topical Terms:

1017686
Biology, Cell.

Multi-level regulation of cyclin D3 controls pre-B cell expansion.
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502 $a Thesis (Ph.D.)--The University of Chicago, 2007.
520 $a During hematopoiesis, stem cell proliferation is dependent upon expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Analysis of Ccnd1-/-, Ccnd2-/-, Ccnd3-/- and Ccnd2-/-Ccnd3-/- mice revealed that cyclin D3 is uniquely required for the proliferative expansion of pre-B cells. Transcription of Ccnd3 is activated before the pro-B stage of development in a process dependent on expression of the common gamma chain of cytokine receptors. In contrast, expression of the pre-BCR and the activation of downstream signaling pathways involving Src and PI3K, but not BLNK, prevent proteasome-mediated cyclin D3 degradation. Additionally signaling through the IL-7 receptor regulates cyclin D3 expression via a mechanism independent of protein stability or transcription, possibly through translational regulation. Cyclin D3 plays a key role in B cell development by integrating cytokine and pre-BCR dependent signals at the appropriate developmental stage in order to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.
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