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The relationship of vitamins C and E...

Millen, Amy Elizabeth.

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The relationship of vitamins C and E to diabetic retinopathy in population studies.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The relationship of vitamins C and E to diabetic retinopathy in population studies./
作者:	Millen, Amy Elizabeth.
面頁冊數:	207 p.
附註:	Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1790.
Contained By:	Dissertation Abstracts International63-04B.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3049477
ISBN:	0493638318

The relationship of vitamins C and E to diabetic retinopathy in population studies.
Millen, Amy Elizabeth.

The relationship of vitamins C and E to diabetic retinopathy in population studies. - 207 p.

Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1790.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2002.

An epidemiological approach was taken to investigate the relationship between the intake and serum concentrations of vitamins C and E to the risk of diabetic retinopathy, a disease of the retinal capillaries.

ISBN: 0493638318Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

The relationship of vitamins C and E to diabetic retinopathy in population studies.
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245 1 0 $a The relationship of vitamins C and E to diabetic retinopathy in population studies.
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500 $a Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1790.
500 $a Supervisor: Julie A. Mares-Perlman.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2002.
520 $a An epidemiological approach was taken to investigate the relationship between the intake and serum concentrations of vitamins C and E to the risk of diabetic retinopathy, a disease of the retinal capillaries.
520 $a We first undertook two studies to evaluate the quality of nutrient estimates made in individuals with diabetes. One study evaluated the reliability of recalled long-term dietary data. A second study evaluated the stability of dietary intake and investigated whether the variability in nutrient intake was related to diabetic complications and their risk factors. Results of these investigations guided our interpretation of subsequent analyses of associations of diet and retinopathy.
520 $a Epidemiological analyses that evaluate the long-term relationship of vitamins C and E to retinopathy in populations of individuals with diabetes across time, research designs and study samples are needed to assess the overall importance of these relationships in the population. Associations between vitamins C and E and retinopathy among individuals with diabetes were investigated in the Beaver Dam Eye Study (BDES), the Third National Health and Nutrition Examination Survey (NHANES III), and the Atherosclerosis Risk in Communities (ARIC) Study.
520 $a Overall, relationships of vitamin C to retinopathy were inconsistent across the population studies. High intake of vitamin C and citrus fruit consumption was associated with lower risk for incident retinopathy in the BDES. The risk of prevalent retinopathy was increased, albeit not statistically significant, with increasing concentrations of serum ascorbic acid in NHANES III. In ARIC, there was no association observed between vitamin C intake and risk of prevalent retinopathy.
520 $a The relationships of vitamin E to retinopathy were inconsistent as well. High intake of vitamin E was not associated with lower risk for incident retinopathy in the BDES or prevalent retinopathy in ARIC. In NHANES III, the risk of prevalent retinopathy was increased with increasing levels of serum α-tocopherol concentrations.
520 $a These studies represent the majority of epidemiological data investigating the relationship between micronutrient intake and retinopathy. The inconsistency of results in light of the strong biologic plausibility and indication of protective effects in short-term clinical studies suggests that the evaluation of these relationships requires prospective longitudinal studies.
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