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Soy isoflavones modulated antioxidan...

Chen, Chung-Yen.

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Soy isoflavones modulated antioxidant defense systems and decreased lipid peroxidation in rats and humans.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Soy isoflavones modulated antioxidant defense systems and decreased lipid peroxidation in rats and humans./
作者:	Chen, Chung-Yen.
面頁冊數:	288 p.
附註:	Chair: Raga M. Bakhit.
Contained By:	Dissertation Abstracts International62-08B.
標題:	Health Sciences, Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3023406
ISBN:	0493349308

Soy isoflavones modulated antioxidant defense systems and decreased lipid peroxidation in rats and humans.
Chen, Chung-Yen.

Soy isoflavones modulated antioxidant defense systems and decreased lipid peroxidation in rats and humans. - 288 p.

Chair: Raga M. Bakhit.

Thesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2001.

Isoflavones have antioxidant activities in vivo, however, their antioxidative potential against oxidative stress initiated by exercise was not explored. The first study investigated the effect of high genistin isoflavone (HGI) supplementation on erythrocyte antioxidant enzymes and tissues' thiobarbituric reactive substances (TBARS) in acutely exercised one-year old rats. All tissue genistein concentrations increased after exercise. Ingestion of HGI seemingly enhanced running time to exhaustion, and maintained glutathione peroxidase (GPx) and catalase (CAT) activities decreased due to exercise. The second study investigated the dose effect of HGI supplementation. Genistein concentrations were significantly higher (P < 0.05) in tissues of rats fed the 1045 PPM HGI diet than in rats fed 522 or 209 PPM HGI diets and increased the glutathione (GSH)/total glutathione (TGSH) ratio (P < 0.03). Reductions of the in vivo MDA concentrations (P < 0.05) were observed only in the plasma of rats fed 522 and 1045 PPM HGI diets compared to those fed 0 PPM (−1.08, −0.82, and 0.03 μM, respectively). Therefore, isoflavones at 522–1045 PPM HGI diet have antioxidative effects in rats.

ISBN: 0493349308Subjects--Topical Terms:

1017801
Health Sciences, Nutrition.

Soy isoflavones modulated antioxidant defense systems and decreased lipid peroxidation in rats and humans.
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100 1 $a Chen, Chung-Yen. $3 1262626
245 1 0 $a Soy isoflavones modulated antioxidant defense systems and decreased lipid peroxidation in rats and humans.
300 $a 288 p.
500 $a Chair: Raga M. Bakhit.
500 $a Source: Dissertation Abstracts International, Volume: 62-08, Section: B, page: 3561.
502 $a Thesis (Ph.D.)--Virginia Polytechnic Institute and State University, 2001.
520 $a Isoflavones have antioxidant activities in vivo, however, their antioxidative potential against oxidative stress initiated by exercise was not explored. The first study investigated the effect of high genistin isoflavone (HGI) supplementation on erythrocyte antioxidant enzymes and tissues' thiobarbituric reactive substances (TBARS) in acutely exercised one-year old rats. All tissue genistein concentrations increased after exercise. Ingestion of HGI seemingly enhanced running time to exhaustion, and maintained glutathione peroxidase (GPx) and catalase (CAT) activities decreased due to exercise. The second study investigated the dose effect of HGI supplementation. Genistein concentrations were significantly higher (P < 0.05) in tissues of rats fed the 1045 PPM HGI diet than in rats fed 522 or 209 PPM HGI diets and increased the glutathione (GSH)/total glutathione (TGSH) ratio (P < 0.03). Reductions of the in vivo MDA concentrations (P < 0.05) were observed only in the plasma of rats fed 522 and 1045 PPM HGI diets compared to those fed 0 PPM (−1.08, −0.82, and 0.03 μM, respectively). Therefore, isoflavones at 522–1045 PPM HGI diet have antioxidative effects in rats.
520 $a The last two studies investigated the effect of isoflavone supplementation on the modulation of erythrocyte antioxidant enzyme activities, glutathione homeostasis, and other oxidative biomolecules in healthy young men undergoing 80%VO2pk exercise. In Study 3 exercise at 80%VO2pk increased oxidative stress which was best demonstrated by increased superoxide dismutase (SOD) activity (16.5%), GSH/TGSH ratio, in vivo MDA (12.6%), plasma uric acid (4.9%) and ferric reducing/antioxidant ability (FRAP) (7.8%). Therefore, 30 minutes 80% VO2pk exercise induced oxidative stress in moderately active college men. In study 4, four-week HGI supplementation produced plasma genistein and daidzein concentrations of 499 and 415 ng/ml, which were significantly increased to 633 and 539 ng/ml by exercise (P = 0.04 and P = 0.05). Isoflavones significantly decreased in vivo pre-exercise plasma MDA (P < 0.05), increased pre-exercise blood TGSH (P = 0.01) and preexercise erythrocyte SOD activity (P = 0.0006), and maintained the decreased activities of GPx due to exercise at pre-exercise levels. Results demonstrated that isoflavones had antioxidant activity in vivo under normal physiological conditions in healthy young men. They also maintaining GPx activity which was decreased due to exercise, however, isoflavones may not overcome all oxidative stress initiated by intense exercise.
590 $a School code: 0247.
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