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Differential roles for sarcKATP and ...

Kanji, Hussein Diamondali.

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Differential roles for sarcKATP and mitoKATP channels in hypoxia and reoxygenation injury: A study of cell viability and ion channel pharmacology.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Differential roles for sarcKATP and mitoKATP channels in hypoxia and reoxygenation injury: A study of cell viability and ion channel pharmacology./
作者:	Kanji, Hussein Diamondali.
面頁冊數:	104 p.
附註:	Adviser: Robert French.
Contained By:	Masters Abstracts International40-04.
標題:	Health Sciences, Medicine and Surgery. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ64965
ISBN:	0612649652

Differential roles for sarcKATP and mitoKATP channels in hypoxia and reoxygenation injury: A study of cell viability and ion channel pharmacology.
Kanji, Hussein Diamondali.

Differential roles for sarcKATP and mitoKATP channels in hypoxia and reoxygenation injury: A study of cell viability and ion channel pharmacology. - 104 p.

Adviser: Robert French.

Thesis (M.Sc.)--University of Calgary (Canada), 2001.

Ischemic preconditioning is a novel cardioprotective mechanism in the heart. ATP-sensitive K (KATP) channels have been suggested as key elements of this pathway; however, their mechanisms of activation and involvement remain unclear. To determine the ability of the plasma membrane KATP (sarcKATP) and mitochondrial KATP (mitoK ATP) channels to mitigate injury, calcium overload and trypan blue viability assays were conducted. In addition, characterization of a new sarcKATP selective drug, HMR 1098, was performed by patch clamp experiments. Testing of HMR 1098 on a number of different K<super>+</super>-channels showed a selective, dose-dependent block of the cardiac sarcKATP channel. Calcium loading experiments and viability assays demonstrated that both sarcK ATP and mitoKATP channels afford some level of protection at different, well-defined stages of the response to metabolic stress. The data also suggest that PKC stimulation as well as adenosine-A 1 receptor activation can mediate this effect via activation of the sarc and mito KATP channels.

ISBN: 0612649652Subjects--Topical Terms:

1017756
Health Sciences, Medicine and Surgery.

Differential roles for sarcKATP and mitoKATP channels in hypoxia and reoxygenation injury: A study of cell viability and ion channel pharmacology.
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520 $a Ischemic preconditioning is a novel cardioprotective mechanism in the heart. ATP-sensitive K (KATP) channels have been suggested as key elements of this pathway; however, their mechanisms of activation and involvement remain unclear. To determine the ability of the plasma membrane KATP (sarcKATP) and mitochondrial KATP (mitoK ATP) channels to mitigate injury, calcium overload and trypan blue viability assays were conducted. In addition, characterization of a new sarcKATP selective drug, HMR 1098, was performed by patch clamp experiments. Testing of HMR 1098 on a number of different K<super>+</super>-channels showed a selective, dose-dependent block of the cardiac sarcKATP channel. Calcium loading experiments and viability assays demonstrated that both sarcK ATP and mitoKATP channels afford some level of protection at different, well-defined stages of the response to metabolic stress. The data also suggest that PKC stimulation as well as adenosine-A 1 receptor activation can mediate this effect via activation of the sarc and mito KATP channels.
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