語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Respiratory tract and systemic respo...
~
Calderon-Garciduenas, Lilian.
FindBook
Google Book
Amazon
博客來
Respiratory tract and systemic responses in clinically healthy children exposed to the atmospheric pollution in southwest Mexico City.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Respiratory tract and systemic responses in clinically healthy children exposed to the atmospheric pollution in southwest Mexico City./
作者:
Calderon-Garciduenas, Lilian.
面頁冊數:
216 p.
附註:
Co-Advisers: Robert B. Devlin; Milan J. Hazucha.
Contained By:
Dissertation Abstracts International62-03B.
標題:
Health Sciences, Public Health. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3007776
ISBN:
0493172092
Respiratory tract and systemic responses in clinically healthy children exposed to the atmospheric pollution in southwest Mexico City.
Calderon-Garciduenas, Lilian.
Respiratory tract and systemic responses in clinically healthy children exposed to the atmospheric pollution in southwest Mexico City.
- 216 p.
Co-Advisers: Robert B. Devlin; Milan J. Hazucha.
Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2001.
Lifelong exposures to ambient air pollutants of clinically healthy children may have clinically important consequences. Southwest Metropolitan Mexico City (SWMMC) children are chronically and sequentially exposed to complex mixtures of air pollutants, predominantly ozone and particulate matter. We have investigated the association between exposure to the SWMMC atmosphere and nasal gross mucosal abnormalities, hyperinflation and interstitial markings assessed in chest-x rays, lung function changes, as well as serum cytokines in a cohort of 174 children ages 5–17 years. These observations were compared to a control group of 19 children residents in a low-polluted area. Children in the control group have no nasal lesions and only one child showed an abnormal chest x ray. Twenty two per cent of SWMMC children exhibited nasal mucosal abnormalities, 67% hyperinflation and 49% interstitial markings. Ten percent had spirometric abnormalities primarily a mild obstructive or restrictive pattern. We found a significant negative association between the key spirometric variables forced expiratory vital capacity (FVC) and forced expiratory volume in 1 second (FEV<sub>1</sub>) and increases in concentrations of ozone and PM<sub>10</sub>. Peripheral blood smear findings included toxic granulations in PMN, schistocytes, and rare giant platelets. SWMMC children had significantly less IL8 serum concentrations when compared to controls. Chronic inhalation of a complex mixture of air pollutants is associated with respiratory tract damage in healthy children living in SWMMC. The radiological abnormalities and spirometric changes suggest the development of small airway disease. Exposed children have a down-regulation of IL8 and this imbalance is most likely the result of the attempts of healthy children to limit the inflammatory responses in the respiratory tract. Thus, these children are potentially at risk of developing chronic lung disease and other systemic effects later in life.
ISBN: 0493172092Subjects--Topical Terms:
1017659
Health Sciences, Public Health.
Respiratory tract and systemic responses in clinically healthy children exposed to the atmospheric pollution in southwest Mexico City.
LDR
:03051nam 2200301 a 45
001
935824
005
20110510
008
110510s2001 eng d
020
$a
0493172092
035
$a
(UnM)AAI3007776
035
$a
AAI3007776
040
$a
UnM
$c
UnM
100
1
$a
Calderon-Garciduenas, Lilian.
$3
1259527
245
1 0
$a
Respiratory tract and systemic responses in clinically healthy children exposed to the atmospheric pollution in southwest Mexico City.
300
$a
216 p.
500
$a
Co-Advisers: Robert B. Devlin; Milan J. Hazucha.
500
$a
Source: Dissertation Abstracts International, Volume: 62-03, Section: B, page: 1346.
502
$a
Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2001.
520
$a
Lifelong exposures to ambient air pollutants of clinically healthy children may have clinically important consequences. Southwest Metropolitan Mexico City (SWMMC) children are chronically and sequentially exposed to complex mixtures of air pollutants, predominantly ozone and particulate matter. We have investigated the association between exposure to the SWMMC atmosphere and nasal gross mucosal abnormalities, hyperinflation and interstitial markings assessed in chest-x rays, lung function changes, as well as serum cytokines in a cohort of 174 children ages 5–17 years. These observations were compared to a control group of 19 children residents in a low-polluted area. Children in the control group have no nasal lesions and only one child showed an abnormal chest x ray. Twenty two per cent of SWMMC children exhibited nasal mucosal abnormalities, 67% hyperinflation and 49% interstitial markings. Ten percent had spirometric abnormalities primarily a mild obstructive or restrictive pattern. We found a significant negative association between the key spirometric variables forced expiratory vital capacity (FVC) and forced expiratory volume in 1 second (FEV<sub>1</sub>) and increases in concentrations of ozone and PM<sub>10</sub>. Peripheral blood smear findings included toxic granulations in PMN, schistocytes, and rare giant platelets. SWMMC children had significantly less IL8 serum concentrations when compared to controls. Chronic inhalation of a complex mixture of air pollutants is associated with respiratory tract damage in healthy children living in SWMMC. The radiological abnormalities and spirometric changes suggest the development of small airway disease. Exposed children have a down-regulation of IL8 and this imbalance is most likely the result of the attempts of healthy children to limit the inflammatory responses in the respiratory tract. Thus, these children are potentially at risk of developing chronic lung disease and other systemic effects later in life.
590
$a
School code: 0153.
650
4
$a
Health Sciences, Public Health.
$3
1017659
650
4
$a
Health Sciences, Radiology.
$3
1019076
650
4
$a
Health Sciences, Toxicology.
$3
1017752
690
$a
0383
690
$a
0573
690
$a
0574
710
2 0
$a
The University of North Carolina at Chapel Hill.
$3
1017449
773
0
$t
Dissertation Abstracts International
$g
62-03B.
790
$a
0153
790
1 0
$a
Devlin, Robert B.,
$e
advisor
790
1 0
$a
Hazucha, Milan J.,
$e
advisor
791
$a
Ph.D.
792
$a
2001
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3007776
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9106410
電子資源
11.線上閱覽_V
電子書
EB W9106410
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入