東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

The role of gene duplication in the ...

McClintock, James Marshall.

FindBook

Google Book

Amazon

博客來

The role of gene duplication in the evolution of vertebrate Hox gene function.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	The role of gene duplication in the evolution of vertebrate Hox gene function./
作者:	McClintock, James Marshall.
面頁冊數:	145 p.
附註:	Adviser: Victoria Prince.
Contained By:	Dissertation Abstracts International64-01B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3077066
ISBN:	0493977414

The role of gene duplication in the evolution of vertebrate Hox gene function.
McClintock, James Marshall.

The role of gene duplication in the evolution of vertebrate Hox gene function. - 145 p.

Adviser: Victoria Prince.

Thesis (Ph.D.)--The University of Chicago, 2003.

Gene duplication has long been thought to play a key role in the evolution of gene function, and hence the evolution of morphology. The vertebrate lineage in particular has been shaped by multiple rounds of large-scale gene duplication, leading to the expansion of many well-studied gene families. As a result of a whole-genome duplication in the lineage leading to teleost fish, zebrafish possess additional copies of many genes relative to their tetrapod counterparts. Amongst these are the Hox genes, a conserved family of transcription factors known to play a key role in anterior to posterior pattern formation during animal development. Whereas mouse and human possess 39 Hox genes arranged in four clusters, zebrafish have 48 Hox genes found over seven clusters. We have used one related group of Hox genes (those in paralog group 1) to examine the effects of gene duplication on the evolution of gene function. In the mouse, these genes play a key role in both proper segmentation of the hindbrain and formation of appropriate segmental identity. We find that these hindbrain patterning functions are present in the zebrafish, but are distributed in a different manner amongst the genes of paralog group 1. Thus, it appears that while Hox gene functions have been conserved in distantly related vertebrates, some functions may be played by paralogous rather than orthologous genes. Furthermore, we have uncovered a non-canonical expression for the zebrafish <italic> hoxa1a</italic> gene in the midbrain, well anterior to the segmented nervous system regions thought to be under Hox control. Comparison of <italic>Hoxa1 </italic> expression in a range of species reveals that this expression domain is actually conserved among the vertebrates, and had previously been overlooked in both mouse and chick. Thus, these studies have demonstrated a conserved and previously unknown role for Hox genes in the midbrain, and highlight the types of modifications that occur within duplicated gene families.

ISBN: 0493977414Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

The role of gene duplication in the evolution of vertebrate Hox gene function.
LDR:02908nam 2200289 a 45 001 934735
005 20110509
008 110509s2003 eng d
020 $a 0493977414
035 $a (UnM)AAI3077066
035 $a AAI3077066
040 $a UnM $c UnM
100 1 $a McClintock, James Marshall. $3 1258434
245 1 0 $a The role of gene duplication in the evolution of vertebrate Hox gene function.
300 $a 145 p.
500 $a Adviser: Victoria Prince.
500 $a Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0053.
502 $a Thesis (Ph.D.)--The University of Chicago, 2003.
520 $a Gene duplication has long been thought to play a key role in the evolution of gene function, and hence the evolution of morphology. The vertebrate lineage in particular has been shaped by multiple rounds of large-scale gene duplication, leading to the expansion of many well-studied gene families. As a result of a whole-genome duplication in the lineage leading to teleost fish, zebrafish possess additional copies of many genes relative to their tetrapod counterparts. Amongst these are the Hox genes, a conserved family of transcription factors known to play a key role in anterior to posterior pattern formation during animal development. Whereas mouse and human possess 39 Hox genes arranged in four clusters, zebrafish have 48 Hox genes found over seven clusters. We have used one related group of Hox genes (those in paralog group 1) to examine the effects of gene duplication on the evolution of gene function. In the mouse, these genes play a key role in both proper segmentation of the hindbrain and formation of appropriate segmental identity. We find that these hindbrain patterning functions are present in the zebrafish, but are distributed in a different manner amongst the genes of paralog group 1. Thus, it appears that while Hox gene functions have been conserved in distantly related vertebrates, some functions may be played by paralogous rather than orthologous genes. Furthermore, we have uncovered a non-canonical expression for the zebrafish <italic> hoxa1a</italic> gene in the midbrain, well anterior to the segmented nervous system regions thought to be under Hox control. Comparison of <italic>Hoxa1 </italic> expression in a range of species reveals that this expression domain is actually conserved among the vertebrates, and had previously been overlooked in both mouse and chick. Thus, these studies have demonstrated a conserved and previously unknown role for Hox genes in the midbrain, and highlight the types of modifications that occur within duplicated gene families.
590 $a School code: 0330.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
690 $a 0307
690 $a 0369
690 $a 0433
710 2 0 $a The University of Chicago. $3 1017389
773 0 $t Dissertation Abstracts International $g 64-01B.
790 $a 0330
790 1 0 $a Prince, Victoria, $e advisor
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3077066