東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Role of Helicobacter pylori catalyse...

Chan, Chi Wai Michael.

FindBook

Google Book

Amazon

博客來

Role of Helicobacter pylori catalysed N-nitrosation in gastric carcinogenesis.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Role of Helicobacter pylori catalysed N-nitrosation in gastric carcinogenesis./
作者:	Chan, Chi Wai Michael.
面頁冊數:	272 p.
附註:	Adviser: Joseph J. Y. Sung.
Contained By:	Dissertation Abstracts International63-10B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3066611
ISBN:	0493859756

Role of Helicobacter pylori catalysed N-nitrosation in gastric carcinogenesis.
Chan, Chi Wai Michael.

Role of Helicobacter pylori catalysed N-nitrosation in gastric carcinogenesis. - 272 p.

Adviser: Joseph J. Y. Sung.

Thesis (Ph.D.)--Chinese University of Hong Kong (People's Republic of China), 2002.

Chronic <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection and exposure to endogenously formed <italic>N</italic>-nitroso-compounds (NOC) are considered the two most important contributing factors in gastric carcinogenesis.

ISBN: 0493859756Subjects--Topical Terms:

1017734
Biology, Microbiology.

Role of Helicobacter pylori catalysed N-nitrosation in gastric carcinogenesis.
LDR:04288nam 2200349 a 45 001 934039
005 20110509
008 110509s2002 eng d
020 $a 0493859756
035 $a (UnM)AAI3066611
035 $a AAI3066611
040 $a UnM $c UnM
100 1 $a Chan, Chi Wai Michael. $3 1257765
245 1 0 $a Role of Helicobacter pylori catalysed N-nitrosation in gastric carcinogenesis.
300 $a 272 p.
500 $a Adviser: Joseph J. Y. Sung.
500 $a Source: Dissertation Abstracts International, Volume: 63-10, Section: B, page: 4587.
502 $a Thesis (Ph.D.)--Chinese University of Hong Kong (People's Republic of China), 2002.
520 $a Chronic <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection and exposure to endogenously formed <italic>N</italic>-nitroso-compounds (NOC) are considered the two most important contributing factors in gastric carcinogenesis.
520 $a We set up an <italic>N</italic>-nitrosating activity of <italic>H. pylori </italic> in an <italic>in-vitro</italic> system using gas chromatography-mass spectrometry (GC-MS) to quantify the production of <italic>N</italic>-nitroso-morpholine (NMOR).
520 $a These series of studies endeavors to investigate the <italic>N</italic>-nitrosating activities that are catalysed by <italic>H. pylori</italic> and its regulation. The frequency of <italic>H. pylori vacA</italic> alleles, <italic>iceA, babA2 </italic> and <italic>cagA</italic> genotype and their relation with <italic> N</italic>-nitrosating abilities of <italic>H. pylori</italic> is also investigated.
520 $a In this <italic>in-vitro</italic> study, the rate of <italic>N</italic>-nitrosating activity is studied at different pH, nitrite and vitamin C levels. The rate of <italic>N</italic>-nitrosation is increased significantly with higher concentrations of nitrite. The increasing concentration of secondary amines also enhances NOC formation albeit only a modest effect. This suggests that high salt-diet induces synthesis of NOC by <italic>H. pylori N</italic>-nitrosation whereas ascorbic acid and tocopherol significantly inhibits the formation of NOC by <italic> H. pylori</italic> in a dose-dependent manner.
520 $a We studied the <italic>N</italic>-nitrosating activity of <italic>H. pylori</italic> strains from Hong Kong (n = 107) and Yantai (n = 63, a region known to have a high incidence of gastric cancer in Mainland China). Our studies showed that <italic>H. pylori</italic> could catalyse <italic>N</italic>-nitrosation and produce the carcinogenic NOC <italic>in-vitro</italic>. Strains isolated from patients with stomach cancer and intestinal metaplasia (IM) tends to express a higher level of <italic>N</italic>-nitrosating activity than those found in non-cancer patients. This study suggests that <italic>H. pylori</italic> catalysed <italic>N</italic>-nitrosation may contribute to gastric carcinogenesis.
520 $a Infection with <italic>H. pylori</italic> induces life-long chronic active gastritis, but only a subset of infected individuals will develop clinically relevant disease. It has been suggested that the bacterial virulence factors, such as <italic>vacA, cagA, iceA</italic> and <italic>babA2</italic>, contribute to the development of gastroduodenal disease. The frequency of <italic>vacA </italic> alleles, <italic>iceA, babA2</italic> and <italic>cagA</italic> in different <italic>H. pylori</italic> genotypes isolated from different disease categories (patients with chronic gastritis, n = 110; ulcer, n = 28; intestinal metaplasia, n = 55 and gastric cancer, n = 20) was investigated and correlated with the rate of <italic>N</italic>-nitrosation of <italic> H. pylori</italic> isolate. Our studies demonstrated that the <italic>vacA m1</italic> genotype of <italic>H. pylori</italic> is associated with gastric cancer and those <italic>H. pylori</italic> strains had a higher mean <italic> N</italic>-nitrosation. (Abstract shortened by UMI.)
590 $a School code: 1307.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0410
690 $a 0564
690 $a 0992
710 2 0 $a Chinese University of Hong Kong (People's Republic of China). $3 1249360
773 0 $t Dissertation Abstracts International $g 63-10B.
790 $a 1307
790 1 0 $a Sung, Joseph J. Y., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3066611