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Molecular abnormalities in microdiss...

Chan, Siu-Chung Andrew.

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Molecular abnormalities in microdissected histologically normal epithelia, preinvasive lesions, and invasive carcinoma of the nasopharynx from endemic and non-endemic regions.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Molecular abnormalities in microdissected histologically normal epithelia, preinvasive lesions, and invasive carcinoma of the nasopharynx from endemic and non-endemic regions./
作者:	Chan, Siu-Chung Andrew.
面頁冊數:	194 p.
附註:	Adviser: H. K. Ng.
Contained By:	Dissertation Abstracts International61-10B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9991351
ISBN:	0599988053

Molecular abnormalities in microdissected histologically normal epithelia, preinvasive lesions, and invasive carcinoma of the nasopharynx from endemic and non-endemic regions.
Chan, Siu-Chung Andrew.

Molecular abnormalities in microdissected histologically normal epithelia, preinvasive lesions, and invasive carcinoma of the nasopharynx from endemic and non-endemic regions. - 194 p.

Adviser: H. K. Ng.

Thesis (Ph.D.)--Chinese University of Hong Kong (People's Republic of China), 2001.

ISBN: 0599988053Subjects--Topical Terms:

1017730
Biology, Genetics.

Molecular abnormalities in microdissected histologically normal epithelia, preinvasive lesions, and invasive carcinoma of the nasopharynx from endemic and non-endemic regions.
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100 1 $a Chan, Siu-Chung Andrew. $3 1256414
245 1 0 $a Molecular abnormalities in microdissected histologically normal epithelia, preinvasive lesions, and invasive carcinoma of the nasopharynx from endemic and non-endemic regions.
300 $a 194 p.
500 $a Adviser: H. K. Ng.
500 $a Source: Dissertation Abstracts International, Volume: 61-10, Section: B, page: 5247.
502 $a Thesis (Ph.D.)--Chinese University of Hong Kong (People's Republic of China), 2001.
520 $a
520 $a The molecular genetic basis for the development of nasopharyngeal carcinoma (NPC) is still unclear. Elucidation of the contribution of genetic changes evidenced by loss of heterozygosity (LOH) analysis and infection with the Epstein-Barr virus (EBV) is fundamental to understanding the development of this important cancer.
520 $a In order to characterize the genetic alterations that occur early in the development of NPC, and the epidemiological features of this cancer, I analyzed microdissected nasopharyngeal tissues from 38 NPC patients (21 from Hong Kong, 8 from Northern China, and 9 from Canada), 52 non-NPC patients with normal-looking epithelia (10 from aborted fetuses and 23 from adults in Hong Kong, 10 from Northern China, and 9 from Canada), and 8 non-NPC patients with dysplastic tissues in Hong Kong. A panel of 5 polymorphic markers localized to chromosome 3p, and 3 markers localized to chromosome 9p were utilized to examine the tissues for chromosome 3p and 9p LOH. Epstein-Barr virus encoded RNA in-situ hybridization (EBER-ISH) was used to determine the presence of EBV in these specimens.
520 $a All of the NPCs from Hong Kong and Northern China showed evidence of chromosome 3p deletion. Caucasian NPC patients showed a somewhat lower frequency of 3p LOH (67%). None of the fetal NP tissue showed evidence of 3p LOH. Strikingly, 74% of Hong Kong normal NP epithelia showed 3p LOH while only 18.8% and 21.4% of NP epithelia from central/northern Chinese and Caucasians showed 3p LOH, respectively. The frequency of 3p LOH in dysplastic NP (75%) and normal NP was similar. The peritumoral NP epithelia showed a lower frequency of 3p LOH (60%) as compared to the dysplastic lesions and normal adult NP tissue.
520 $a These results demonstrate, for the first time, the presence of genetically abnormal clones in the epithelium of the nasopharynx. Moreover, our data suggest that genetic alterations occur prior to the occurrence of dysplastic changes. (Abstract shortened by UMI.)
590 $a School code: 1307.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0307
690 $a 0369
690 $a 0571
710 2 0 $a Chinese University of Hong Kong (People's Republic of China). $3 1249360
773 0 $t Dissertation Abstracts International $g 61-10B.
790 $a 1307
790 1 0 $a Ng, H. K., $e advisor
791 $a Ph.D.
792 $a 2001
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