語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Supercritical fluid technology for p...
~
Sacha, Gregory A.
FindBook
Google Book
Amazon
博客來
Supercritical fluid technology for particle size reduction.
紀錄類型:
書目-語言資料,印刷品 : Monograph/item
正題名/作者:
Supercritical fluid technology for particle size reduction./
作者:
Sacha, Gregory A.
面頁冊數:
110 p.
附註:
Major Professor: Steven L. Nail.
Contained By:
Dissertation Abstracts International60-11B.
標題:
Health Sciences, Pharmacy. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9952170
ISBN:
0599539372
Supercritical fluid technology for particle size reduction.
Sacha, Gregory A.
Supercritical fluid technology for particle size reduction.
- 110 p.
Major Professor: Steven L. Nail.
Thesis (Ph.D.)--Purdue University, 1999.
The broad objective of this research is to test the hypothesis that crystallization using supercritical fluid technology is a potentially superior method for size reduction of pharmaceutical solids compared with mechanical milling. The specific aims of this study are (1) To determine the critical process variables affecting particle size, particle size distribution, yield and level of residual carrier solvent, (2) To consistently obtain average particle sizes of 5 μm or less, and (3) To determine the effect of the drug solution composition on particle size.
ISBN: 0599539372Subjects--Topical Terms:
1017737
Health Sciences, Pharmacy.
Supercritical fluid technology for particle size reduction.
LDR
:03217nam 2200289 a 45
001
932636
005
20110505
008
110505s1999 eng d
020
$a
0599539372
035
$a
(UnM)AAI9952170
035
$a
AAI9952170
040
$a
UnM
$c
UnM
100
1
$a
Sacha, Gregory A.
$3
1256377
245
1 0
$a
Supercritical fluid technology for particle size reduction.
300
$a
110 p.
500
$a
Major Professor: Steven L. Nail.
500
$a
Source: Dissertation Abstracts International, Volume: 60-11, Section: B, page: 5458.
502
$a
Thesis (Ph.D.)--Purdue University, 1999.
520
$a
The broad objective of this research is to test the hypothesis that crystallization using supercritical fluid technology is a potentially superior method for size reduction of pharmaceutical solids compared with mechanical milling. The specific aims of this study are (1) To determine the critical process variables affecting particle size, particle size distribution, yield and level of residual carrier solvent, (2) To consistently obtain average particle sizes of 5 μm or less, and (3) To determine the effect of the drug solution composition on particle size.
520
$a
In this study, supercritical carbon dioxide (CO<sub>2</sub>) is used as a non-solvent to cause precipitation of methylprednisolone acetate from various organic solvents resulting in a finely divided powder. The process variables include temperature and pressure of the CO<sub>2</sub>, agitation rate, CO<sub>2</sub> flow rate, drug solution flow rate, and drug solution temperature. The effect of drug solution composition was examined by adjusting the drug concentration, by using different carrier solvents, and by comparing six different steroids after precipitation from tetrahydrofuran. Carrier solvents were chosen based on their dielectric constant and vapor pressure.
520
$a
Results show that yield and level of residual carrier solvent are not affected by the process variables examined in this study, while particle size and particle size distribution are most dependent upon adequate dispersion of the drug solution into the supercritical fluid. Finely dispersing the drug solution, decreasing its rate of addition, and increasing the agitation rate results in the smallest average particle size and narrowest particle size distribution. Concentration of the drug solution does not affect the particle size or particle size distribution, while using carrier solvents possessing a high dielectric constant and/or low vapor pressure results in a larger average particle size. Methylprednisolone acetate resulted in the largest average particle size when compared to the other steroids tested. It was determined that the slightly higher solubility of methylprednisolone acetate in the CO<sub> 2</sub>/solvent mixture lead to the increase in particle size. Under carefully controlled processing conditions, average particle sizes of 5 μm or less are produced.
590
$a
School code: 0183.
650
4
$a
Health Sciences, Pharmacy.
$3
1017737
690
$a
0572
710
2 0
$a
Purdue University.
$3
1017663
773
0
$t
Dissertation Abstracts International
$g
60-11B.
790
$a
0183
790
1 0
$a
Nail, Steven L.,
$e
advisor
791
$a
Ph.D.
792
$a
1999
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9952170
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9103324
電子資源
11.線上閱覽_V
電子書
EB W9103324
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入