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Neurotrophins, synaptic connectivity...

Kittelberger, James Matthew.

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Neurotrophins, synaptic connectivity and the regulation of song plasticity in the zebra finch.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Neurotrophins, synaptic connectivity and the regulation of song plasticity in the zebra finch./
Author:	Kittelberger, James Matthew.
Description:	218 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0093.
Contained By:	Dissertation Abstracts International64-01B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3077141
ISBN:	0493975586

Neurotrophins, synaptic connectivity and the regulation of song plasticity in the zebra finch.
Kittelberger, James Matthew.

Neurotrophins, synaptic connectivity and the regulation of song plasticity in the zebra finch. - 218 p.

Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0093.

Thesis (Ph.D.)--Duke University, 2002.

Young animals display heightened behavioral plasticity and learning abilities during defined developmental sensitive periods. Characterizing neural mechanisms enabling enhanced sensitive period behavioral plasticity is central to an understanding of the neurobiological bases of learned behavior. Oscine songbirds learn to sing by matching their song to a previously memorized model during a sensitive period for sensorimotor learning. During this time, song is highly variable, or plastic, as compared to the stereotyped, stable songs of adults. Here, I describe experiments to elucidate neural correlates of vocal plasticity across the sensitive period for sensorimotor learning in the zebra finch.

ISBN: 0493975586Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Neurotrophins, synaptic connectivity and the regulation of song plasticity in the zebra finch.
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005 20110505
008 110505s2002 eng d
020 $a 0493975586
035 $a (UnM)AAI3077141
035 $a AAI3077141
040 $a UnM $c UnM
100 1 $a Kittelberger, James Matthew. $3 1256349
245 1 0 $a Neurotrophins, synaptic connectivity and the regulation of song plasticity in the zebra finch.
300 $a 218 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-01, Section: B, page: 0093.
500 $a Supervisor: Richard Mooney.
502 $a Thesis (Ph.D.)--Duke University, 2002.
520 $a Young animals display heightened behavioral plasticity and learning abilities during defined developmental sensitive periods. Characterizing neural mechanisms enabling enhanced sensitive period behavioral plasticity is central to an understanding of the neurobiological bases of learned behavior. Oscine songbirds learn to sing by matching their song to a previously memorized model during a sensitive period for sensorimotor learning. During this time, song is highly variable, or plastic, as compared to the stereotyped, stable songs of adults. Here, I describe experiments to elucidate neural correlates of vocal plasticity across the sensitive period for sensorimotor learning in the zebra finch.
520 $a The forebrain nucleus LMAN is necessary for song learning and for maintaining song plasticity, but not for stable adult song production. Within the vocal-motor circuit generating song, the nucleus RA is the sole target of LMAN. One hypothesis is that particular LMAN-dependent aspects of RA circuit structure and function enable vocal plasticity during sensorimotor learning. I tested this hypothesis by examining morphological and electrophysiological properties of RA neurons and synapses: first over normal development, and then in juvenile birds after LMAN lesions that reduce song plasticity and prevent sensorimotor learning. The RA of normal juveniles was characterized by an overproduction of functionally weak synaptic connections. Normal adults and LMAN-lesioned juveniles, both of which sang highly invariant songs, had fewer but stronger synapses. These data suggest that: (1) high numbers of relatively weak synapses in RA contribute to juvenile song plasticity, and (2) LMAN trophically maintains this state of connectivity during sensorimotor learning. Additional experiments showed that over-expression in adult birds of the neurotrophic signaling molecule BDNF caused a restoration of juvenile-like plastic song and an increase in the number of RA's synaptic connections. These data support a model in which LMAN-dependent BDNF expression in RA regulates the number and strength of synapses to enable the circuit and vocal plasticity necessary for sensorimotor learning in juveniles. By this model, developmental declines in BDNF trigger synaptic consolidation within RA, contributing to the closure of the sensitive period and the stabilization of learned song.
590 $a School code: 0066.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Zoology. $3 1018632
690 $a 0317
690 $a 0433
690 $a 0472
710 2 0 $a Duke University. $3 569686
773 0 $t Dissertation Abstracts International $g 64-01B.
790 $a 0066
790 1 0 $a Mooney, Richard, $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3077141