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Opioids and immunity: Characterizat...

The University of North Carolina at Chapel Hill.

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Opioids and immunity: Characterization of the immunomodulatory effects of mu opioid agonists and relevance to susceptibility to infection (Porphyromonas gingivalis).

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Opioids and immunity: Characterization of the immunomodulatory effects of mu opioid agonists and relevance to susceptibility to infection (Porphyromonas gingivalis)./
作者:	Carrigan, Kelly Allison.
面頁冊數:	134 p.
附註:	Director: Donald T. Lysle.
Contained By:	Dissertation Abstracts International63-11B.
標題:	Health Sciences, Immunology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3070831
ISBN:	0493905790

Opioids and immunity: Characterization of the immunomodulatory effects of mu opioid agonists and relevance to susceptibility to infection (Porphyromonas gingivalis).
Carrigan, Kelly Allison.

Opioids and immunity: Characterization of the immunomodulatory effects of mu opioid agonists and relevance to susceptibility to infection (Porphyromonas gingivalis). - 134 p.

Director: Donald T. Lysle.

Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2002.

There is an extensive literature demonstrating that administration of the prototypical mu opioid agonist, morphine produces alterations in numerous immune responses. The present investigations address critical issues remaining in understanding the relationship between opioids and immune function by assessing the immunomodulatory effects of two other mu opioid agonists, morphine-6beta-glucuronide (M6G) and buprenorphine, and examining the translation of these immunomodulatory effects in the context of a live bacterial infection.

ISBN: 0493905790Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Opioids and immunity: Characterization of the immunomodulatory effects of mu opioid agonists and relevance to susceptibility to infection (Porphyromonas gingivalis).
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245 1 0 $a Opioids and immunity: Characterization of the immunomodulatory effects of mu opioid agonists and relevance to susceptibility to infection (Porphyromonas gingivalis).
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500 $a Director: Donald T. Lysle.
500 $a Source: Dissertation Abstracts International, Volume: 63-11, Section: B, page: 5562.
502 $a Thesis (Ph.D.)--The University of North Carolina at Chapel Hill, 2002.
520 $a There is an extensive literature demonstrating that administration of the prototypical mu opioid agonist, morphine produces alterations in numerous immune responses. The present investigations address critical issues remaining in understanding the relationship between opioids and immune function by assessing the immunomodulatory effects of two other mu opioid agonists, morphine-6beta-glucuronide (M6G) and buprenorphine, and examining the translation of these immunomodulatory effects in the context of a live bacterial infection.
520 $a Chapters 2 and 3 assessed the immune altering properties of M6G and buprenorphine, mu opioid agonists that possess differences in mu opioid receptor subtype mediation and efficacy relative to morphine. The results show that both M6G and buprenorphine produce dose dependent suppression of <italic>ex-vivo</italic> splenic natural killer cell activity, lymphocyte proliferation to mitogenic stimulation, and production of the cytokine IFN-γ. Moreover, the results demonstrate that M6G and buprenorphine suppress the <italic>in-vivo</italic> production of LPS-induced nitric oxide and the proinflammatory cytokines, TNF-α and IL-1β. These findings demonstrate that the immunomodulatory effects of morphine are generalizable to other mu opioid agonists and indicate that there is a robust relationship between the opioid and immune systems.
520 $a To evaluate the translation of the immunomodulatory effects of opioids into susceptibility to infection, studies described in Chapter 4 assessed the effects of acute injection of morphine one hour prior to infectious challenge with Pg A7436 in a subcutaneous chamber model of Gram negative sepsis. In control animals, Pg A7436 induces a local inflammatory response and rapidly disseminates from the chamber to the periphery to induce systemic infection and death. The results show that animals administered 20 mg/kg morphine are less susceptible to Pg A7436 induced mortality and show less dissemination of Pg A7436 from the chamber to the blood and spleen. Further studies demonstrated that the protective effects of morphine were correlated with a decrease in vascular permeability enhancement of the chamber and decreased expression of the proinflammatory mediators, TNF-α, IL-1β, IFN-γ, and NO in the chamber and spleen at 3 hours post infection. These findings suggest that suppression of the proinflammatory immune response by opioids may provide beneficial effects in the context of Gram negative sepsis and infectious conditions where robust inflammatory responses result in pathology.
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