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Transcriptional analysis of herpes s...

Stingley, Samuel Wayne.

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Transcriptional analysis of herpes simplex virus type 1 expression and host cell response to infection using a DNA microarray.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Transcriptional analysis of herpes simplex virus type 1 expression and host cell response to infection using a DNA microarray./
作者:	Stingley, Samuel Wayne.
面頁冊數:	258 p.
附註:	Chair: Edward K. Wagner.
Contained By:	Dissertation Abstracts International63-01B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3039229
ISBN:	0493524754

Transcriptional analysis of herpes simplex virus type 1 expression and host cell response to infection using a DNA microarray.
Stingley, Samuel Wayne.

Transcriptional analysis of herpes simplex virus type 1 expression and host cell response to infection using a DNA microarray. - 258 p.

Chair: Edward K. Wagner.

Thesis (Ph.D.)--University of California, Irvine, 2002.

Herpes Simplex Virus Type 1 (HSV-1) infection is a model for much of what is known concerning viral transcription kinetics, evasion of host defenses, and latent infection. Efficient global analysis of HSV-1 infection using microarray technology has great potential to further research in many aspects of virology. With this goal in mind, a custom DNA microarray with probes for both viral and cellular transcripts was developed and validated. A detailed analysis of HSV-1 infection in different cell types was performed to examine differences in HSV-1 transcription and host cell response dependent on cell type. Wildtype HSV-1 expression was similar in HeLa, B7, and SK-N-SH cells. Data from the cellular probes indicate a cell type-specific immune response in B7 fibroblasts, but not in SK-N-SH cells, supporting observations by others. Additionally, similar infections using a mutant virus, 27<italic>lacZ</italic>, which is incapable of expressing the critical ICP27 regulatory protein, provided evidence of a sub-division of the viral early kinetic class of transcripts.

ISBN: 0493524754Subjects--Topical Terms:

1017734
Biology, Microbiology.

Transcriptional analysis of herpes simplex virus type 1 expression and host cell response to infection using a DNA microarray.
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520 $a Herpes Simplex Virus Type 1 (HSV-1) infection is a model for much of what is known concerning viral transcription kinetics, evasion of host defenses, and latent infection. Efficient global analysis of HSV-1 infection using microarray technology has great potential to further research in many aspects of virology. With this goal in mind, a custom DNA microarray with probes for both viral and cellular transcripts was developed and validated. A detailed analysis of HSV-1 infection in different cell types was performed to examine differences in HSV-1 transcription and host cell response dependent on cell type. Wildtype HSV-1 expression was similar in HeLa, B7, and SK-N-SH cells. Data from the cellular probes indicate a cell type-specific immune response in B7 fibroblasts, but not in SK-N-SH cells, supporting observations by others. Additionally, similar infections using a mutant virus, 27<italic>lacZ</italic>, which is incapable of expressing the critical ICP27 regulatory protein, provided evidence of a sub-division of the viral early kinetic class of transcripts.
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