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Characterization of Sindbis virus- a...

Nargi, Jennifer Laura.

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Characterization of Sindbis virus- and antioxidant-induced cell death.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Characterization of Sindbis virus- and antioxidant-induced cell death./
作者:	Nargi, Jennifer Laura.
面頁冊數:	255 p.
附註:	Adviser: Diane E. Griffin.
Contained By:	Dissertation Abstracts International62-02B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3006317
ISBN:	0493156321

Characterization of Sindbis virus- and antioxidant-induced cell death.
Nargi, Jennifer Laura.

Characterization of Sindbis virus- and antioxidant-induced cell death. - 255 p.

Adviser: Diane E. Griffin.

Thesis (Ph.D.)--The Johns Hopkins University, 2001.

Although development and homeostasis of multicellular organisms is critically dependent upon apoptotic cell death, regulation of the cell death process is not fully understood. These studies were designed to identify factors that contribute to Sindbis virus (SV) and antioxidant-induced cell death and to better understand the cell death process following SV infection. The first set of experiments shows that glutamate excitotoxicity contributes to SV-induced death <italic>in vitro</italic> and <italic>in vivo</italic>, that SV-induced death can be either apoptotic or necrotic and that bystander cell death occurs in uninfected cells. The second set of experiments shows that poly (ADP-ribose) polymerase activation contributes to SV-induced apoptotic cell death and examines the role that cyclin-dependent kinase activation plays in cell death following SV infection. The last part of this study identifies cell cycle and cell death regulatory factors involved in antioxidant-induced growth arrest and cell death in colorectal carcinoma cells. These studies contribute to understanding the regulation of apoptotic cell death, a critical process which leads to disease if unregulated.

ISBN: 0493156321Subjects--Topical Terms:

1017734
Biology, Microbiology.

Characterization of Sindbis virus- and antioxidant-induced cell death.
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520 $a Although development and homeostasis of multicellular organisms is critically dependent upon apoptotic cell death, regulation of the cell death process is not fully understood. These studies were designed to identify factors that contribute to Sindbis virus (SV) and antioxidant-induced cell death and to better understand the cell death process following SV infection. The first set of experiments shows that glutamate excitotoxicity contributes to SV-induced death <italic>in vitro</italic> and <italic>in vivo</italic>, that SV-induced death can be either apoptotic or necrotic and that bystander cell death occurs in uninfected cells. The second set of experiments shows that poly (ADP-ribose) polymerase activation contributes to SV-induced apoptotic cell death and examines the role that cyclin-dependent kinase activation plays in cell death following SV infection. The last part of this study identifies cell cycle and cell death regulatory factors involved in antioxidant-induced growth arrest and cell death in colorectal carcinoma cells. These studies contribute to understanding the regulation of apoptotic cell death, a critical process which leads to disease if unregulated.
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