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Changes in clotting and fibrinolytic...

Hegde, Sudhir Sadananda.

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Changes in clotting and fibrinolytic activity after sub-maximal exercise in males.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Changes in clotting and fibrinolytic activity after sub-maximal exercise in males./
Author:	Hegde, Sudhir Sadananda.
Description:	176 p.
Notes:	Chair: Allan H. Goldfarb.
Contained By:	Dissertation Abstracts International60-06B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9933844
ISBN:	0599344539

Changes in clotting and fibrinolytic activity after sub-maximal exercise in males.
Hegde, Sudhir Sadananda.

Changes in clotting and fibrinolytic activity after sub-maximal exercise in males. - 176 p.

Chair: Allan H. Goldfarb.

Thesis (Ph.D.)--The University of North Carolina at Greensboro, 1999.

Risk of AMI and sudden cardiac death, caused by clot formation in the coronary arteries, is increased during the one-hour period following an acute bout of physical exertion. Therefore, the purpose of this study was to determine the changes in clotting and fibrinolytic activity during the one-hour period following an acute bout of sub-maximal exercise at a specific relative intensity of exercise. Ten apparently healthy males (23.5 yr.) ran at 70–75% VO 2 max and walked slowly at 1.2 mph for 30 minutes in random order. Subjects reported in the morning between 07:00 and 10:00 (10–12 hrs, post-absorptive) and rested 15–30 minutes. Venous blood was obtained at rest, immediately (within 2–4 minutes) after the run or walk and every 20-minute during the one hr recovery. Plasma was analyzed for indicators of clotting [activated partial thromboplastin time (APTT) & factor VIII activity (FVIII)] and fibrinolytic activity [t-PA antigen (tPA) & D-dimers (Dd)]. A 2 x 4 repeated measures ANOVA was used to analyze the data.

ISBN: 0599344539Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Changes in clotting and fibrinolytic activity after sub-maximal exercise in males.
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005 20110429
008 110429s1999 eng d
020 $a 0599344539
035 $a (UnM)AAI9933844
035 $a AAI9933844
040 $a UnM $c UnM
100 1 $a Hegde, Sudhir Sadananda. $3 1255051
245 1 0 $a Changes in clotting and fibrinolytic activity after sub-maximal exercise in males.
300 $a 176 p.
500 $a Chair: Allan H. Goldfarb.
500 $a Source: Dissertation Abstracts International, Volume: 60-06, Section: B, page: 2644.
502 $a Thesis (Ph.D.)--The University of North Carolina at Greensboro, 1999.
520 $a Risk of AMI and sudden cardiac death, caused by clot formation in the coronary arteries, is increased during the one-hour period following an acute bout of physical exertion. Therefore, the purpose of this study was to determine the changes in clotting and fibrinolytic activity during the one-hour period following an acute bout of sub-maximal exercise at a specific relative intensity of exercise. Ten apparently healthy males (23.5 yr.) ran at 70–75% VO 2 max and walked slowly at 1.2 mph for 30 minutes in random order. Subjects reported in the morning between 07:00 and 10:00 (10–12 hrs, post-absorptive) and rested 15–30 minutes. Venous blood was obtained at rest, immediately (within 2–4 minutes) after the run or walk and every 20-minute during the one hr recovery. Plasma was analyzed for indicators of clotting [activated partial thromboplastin time (APTT) & factor VIII activity (FVIII)] and fibrinolytic activity [t-PA antigen (tPA) & D-dimers (Dd)]. A 2 x 4 repeated measures ANOVA was used to analyze the data.
520 $a Pre-treatment values (running and walking) were similar for all the dependent variables and not included in the statistical analysis. The post-exercise main effect means of APTT for the running and walking condition were 30.78 and 32.99 sec, respectively [<italic>F</italic>(1,9) = 22.48, <italic>p</italic> = 0.0011]. The post-exercise main effect means of FVIII for the running and walking condition were 195.85 and 128.82%, respectively [<italic>F</italic>(1,9) = 21.79, <italic>p</italic> = 0.0012]. There was a significant time x treatment interaction for changes in tPA [<italic>F</italic>(3,54) = 23.41, <italic> p</italic> < 0.0001]. A quadratic trend with negative slope was present for changes in tPA after the run, while changes after walking showed a linear trend with zero slope. The post-exercise main effect means of Dd for the running and walking condition was 68.36 and 45.31 ng/ml, respectively [<italic> F</italic>(1,9) = 45.68, <italic>p</italic> = <0.0001]. Increased Dd suggests the presence of <italic>in vivo</italic> clot formation and fibrinolysis. There was no main effect of time, or time x treatment interaction for changes in APTT, FVIII and Dd (<italic>p</italic> <math> <f> ≥</f> </math> 0.28). This data suggests that running at 70–75% VO2max results in elevated clotting and fibrinolytic activity which lasted for one-hour post-exercise period. However, sustained clotting activity in conjunction with declining tPA could favor clot formation during this period.
590 $a School code: 0154.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Health Sciences, Recreation. $3 1018003
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
690 $a 0382
690 $a 0433
690 $a 0575
710 2 0 $a The University of North Carolina at Greensboro. $3 1029687
773 0 $t Dissertation Abstracts International $g 60-06B.
790 $a 0154
790 1 0 $a Goldfarb, Allan H., $e advisor
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9933844