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Influence of dietary energy and calc...

Talbott, Shawn M.

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Influence of dietary energy and calcium intake on biochemical and biomechanical properties of bone in younger and older female rats.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Influence of dietary energy and calcium intake on biochemical and biomechanical properties of bone in younger and older female rats./
作者:	Talbott, Shawn M.
面頁冊數:	159 p.
附註:	Director: Susan A. Shapses.
Contained By:	Dissertation Abstracts International59-08B.
標題:	Gerontology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9900707
ISBN:	059197617X

Influence of dietary energy and calcium intake on biochemical and biomechanical properties of bone in younger and older female rats.
Talbott, Shawn M.

Influence of dietary energy and calcium intake on biochemical and biomechanical properties of bone in younger and older female rats. - 159 p.

Director: Susan A. Shapses.

Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 1998.

Loss of body weight reduces bone mass in humans (Jensen 1994) and animals (Lee 1993) and increases fracture risk in older adults (Cummings 1995). Because both dietary intake of energy and calcium are often both reduced during weight loss diets (NIH 1992), this dissertation examined the influence of dietary restriction of energy, calcium or both energy and calcium, on bone turnover, density, and biomechanical properties in younger (3-7 months) and older (10-14 months) female rats. In both age groups, energy restriction resulted in lower serum estradiol and insulin levels, increased bone turnover and lower values for bone size. In younger rats, energy restriction resulted in lower bone density only at the femur, but no difference in bone biomechanical properties compared to energy adequate control rats. In older rats, dietary energy restriction resulted in a lower bone density for the total body, humerus, tibia and femur as well as lower values for biomechanical properties, compared to controls. These results show that the positive relationship between body weight and bone mass is influenced by dietary energy restriction and is dependent on the age and growth rate of the rat. In both age groups, calcium restriction resulted in higher serum parathyroid hormone, elevated bone resorption, lower bone weight and lower bone density compared to calcium-adequate controls. In younger calcium restricted rats, bone biomechanical properties were lower compared to calcium adequate controls, whereas no significant differences were found between older calcium restricted and control rats. In summary, these results indicate that although inadequate calcium intake compromises peak bone mass and skeletal integrity in younger growing rats, energy restriction has no significant effect. In older rats, however, energy restriction resulted in lower bone biomechanical properties, while calcium restriction had no significant effect. These data suggest that adequate energy intake and maintenance of body weight are more important than calcium intake in determining bone strength in these older animals. In addition, these data suggest that older rats are a more appropriate model of human adult bone loss and should be utilized in future studies.

ISBN: 059197617XSubjects--Topical Terms:

533633
Gerontology.

Influence of dietary energy and calcium intake on biochemical and biomechanical properties of bone in younger and older female rats.
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