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Central circulatory control of arter...

Hunt, Brian Edward.

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Central circulatory control of arterial blood pressure and maximal aerobic capacity across age in humans.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Central circulatory control of arterial blood pressure and maximal aerobic capacity across age in humans./
作者:	Hunt, Brian Edward.
面頁冊數:	61 p.
附註:	Director: Douglas R. Seals.
Contained By:	Dissertation Abstracts International59-06B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9838371
ISBN:	0591920719

Central circulatory control of arterial blood pressure and maximal aerobic capacity across age in humans.
Hunt, Brian Edward.

Central circulatory control of arterial blood pressure and maximal aerobic capacity across age in humans. - 61 p.

Director: Douglas R. Seals.

Thesis (Ph.D.)--University of Colorado at Boulder, 1998.

Advancing age is associated with a decline in physical functional capacity and an increase in the incidence of chronic degenerative disease. In order to make significant advances in the maintenance of health and quality of life with advancing age, the physiological mechanisms underlying the adverse changes in risk factors for chronic diseases and physical functional capacity must be identified. Therefore, a series of three studies were performed to help answer two specific experimental questions: (1) what role do central circulatory factors play in the regulation of age-associated increases in arterial blood pressure in healthy women, and what might be the modulatory effect of habitual physical activity in these events? and (2) what role do central circulatory factors play in the regulation of maximal aerobic capacity in sedentary men and women across the adult age range, and what impact might body composition (fat-free mass) have? From these studies we concluded that: (1) chronic physical activity does not attenuate the primary age-related increase in arterial blood pressure; however, this increase in blood pressure appears to be modulated primarily by increased systemic vascular resistance coupled with declines in resting cardiac output and metabolic demand in sedentary women, and by small increases in systemic vascular resistance coupled with a maintenance of resting cardiac output and metabolic oxygen demand in habitually active women; and (2) fat-free mass may significantly modulate maximal aerobic capacity through its influence on total blood volume and subsequently left ventricular stroke volume. Together these studies show that habitual physical activity and changes in body composition, particularly fat-free mass, can have a profound impact on age-related changes in arterial blood pressure and functional capacity through their respective influences on central circulatory function.

ISBN: 0591920719Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Central circulatory control of arterial blood pressure and maximal aerobic capacity across age in humans.
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500 $a Director: Douglas R. Seals.
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502 $a Thesis (Ph.D.)--University of Colorado at Boulder, 1998.
520 $a Advancing age is associated with a decline in physical functional capacity and an increase in the incidence of chronic degenerative disease. In order to make significant advances in the maintenance of health and quality of life with advancing age, the physiological mechanisms underlying the adverse changes in risk factors for chronic diseases and physical functional capacity must be identified. Therefore, a series of three studies were performed to help answer two specific experimental questions: (1) what role do central circulatory factors play in the regulation of age-associated increases in arterial blood pressure in healthy women, and what might be the modulatory effect of habitual physical activity in these events? and (2) what role do central circulatory factors play in the regulation of maximal aerobic capacity in sedentary men and women across the adult age range, and what impact might body composition (fat-free mass) have? From these studies we concluded that: (1) chronic physical activity does not attenuate the primary age-related increase in arterial blood pressure; however, this increase in blood pressure appears to be modulated primarily by increased systemic vascular resistance coupled with declines in resting cardiac output and metabolic demand in sedentary women, and by small increases in systemic vascular resistance coupled with a maintenance of resting cardiac output and metabolic oxygen demand in habitually active women; and (2) fat-free mass may significantly modulate maximal aerobic capacity through its influence on total blood volume and subsequently left ventricular stroke volume. Together these studies show that habitual physical activity and changes in body composition, particularly fat-free mass, can have a profound impact on age-related changes in arterial blood pressure and functional capacity through their respective influences on central circulatory function.
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