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Bootstrap application to the lagrang...

Smith, David Johnston.

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Bootstrap application to the lagrange gamma II dose-response model.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Bootstrap application to the lagrange gamma II dose-response model./
Author:	Smith, David Johnston.
Description:	56 p.
Notes:	Adviser: K. G. Janardan.
Contained By:	Masters Abstracts International40-03.
Subject:	Health Sciences, Toxicology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1407059
ISBN:	0493441484

Bootstrap application to the lagrange gamma II dose-response model.
Smith, David Johnston.

Bootstrap application to the lagrange gamma II dose-response model. - 56 p.

Adviser: K. G. Janardan.

Thesis (M.A.)--Eastern Michigan University, 2001.

There are many factors affecting the certainty associated with determining safe levels of chemicals for humans. One of these is the mathematical uncertainty associated with the dose-response model. A lagrange gamma II dose-response model has been proposed for the analysis of toxicity, given experimental data on animals (Janardan 1995). This model assumes that a toxic response may be the result of multiple random or nonrandom biological events and attempts to assess the risk at low doses based on data generated at higher doses in laboratory studies. The parameters associated with this model must be estimated using a nonlinear iterative algorithm. Here, bootstrap methodology is applied using SAS<super>®</super> software to estimate the parameters, as well as the uncertainty surrounding these parameter estimates.

ISBN: 0493441484Subjects--Topical Terms:

1017752
Health Sciences, Toxicology.

Bootstrap application to the lagrange gamma II dose-response model.
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005 20110427
008 110427s2001 eng d
020 $a 0493441484
035 $a (UnM)AAI1407059
035 $a AAI1407059
040 $a UnM $c UnM
100 1 $a Smith, David Johnston. $3 1252662
245 1 0 $a Bootstrap application to the lagrange gamma II dose-response model.
300 $a 56 p.
500 $a Adviser: K. G. Janardan.
500 $a Source: Masters Abstracts International, Volume: 40-03, page: 0715.
502 $a Thesis (M.A.)--Eastern Michigan University, 2001.
520 $a There are many factors affecting the certainty associated with determining safe levels of chemicals for humans. One of these is the mathematical uncertainty associated with the dose-response model. A lagrange gamma II dose-response model has been proposed for the analysis of toxicity, given experimental data on animals (Janardan 1995). This model assumes that a toxic response may be the result of multiple random or nonrandom biological events and attempts to assess the risk at low doses based on data generated at higher doses in laboratory studies. The parameters associated with this model must be estimated using a nonlinear iterative algorithm. Here, bootstrap methodology is applied using SAS<super>®</super> software to estimate the parameters, as well as the uncertainty surrounding these parameter estimates.
590 $a School code: 6456.
650 4 $a Health Sciences, Toxicology. $3 1017752
650 4 $a Mathematics. $3 515831
650 4 $a Statistics. $3 517247
690 $a 0383
690 $a 0405
690 $a 0463
710 2 0 $a Eastern Michigan University. $3 756769
773 0 $t Masters Abstracts International $g 40-03.
790 $a 6456
790 1 0 $a Janardan, K. G., $e advisor
791 $a M.A.
792 $a 2001
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1407059