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Bcl-2 proteins in human lung cancer:...

Huang, Chris Ing-yi.

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Bcl-2 proteins in human lung cancer: Molecular heterogeneity and prognostic value.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Bcl-2 proteins in human lung cancer: Molecular heterogeneity and prognostic value./
Author:	Huang, Chris Ing-yi.
Description:	121 p.
Notes:	Adviser: David C. Christiani.
Contained By:	Dissertation Abstracts International63-04B.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051190
ISBN:	0493657223

Bcl-2 proteins in human lung cancer: Molecular heterogeneity and prognostic value.
Huang, Chris Ing-yi.

Bcl-2 proteins in human lung cancer: Molecular heterogeneity and prognostic value. - 121 p.

Adviser: David C. Christiani.

Thesis (Ph.D.)--Harvard University, 2002.

The objective of this study is the investigation of the prognostic value of the 27 kD Bcl-2 protein in non-small cell lung cancer (NSCLC) patients. Currently, controversy surrounds the prognostic value of Bcl-2 in lung cancer. We argue that the method of Bcl-2 protein detection might have relevance, as multiple molecular forms of the protein are known to exist. In contrast to immunohistochemistry, the technique used by other investigators, we used Western blot, a more quantifiable method, to analyze Bcl-2 protein, and examined the prognostic value of the presence of Bcl-2 protein in uninvolved lung and in tumor tissues. We also compared adenocarcinoma and squamous cell carcinoma patients, and studied stage I versus stage II tumor patients.

ISBN: 0493657223Subjects--Topical Terms:

1017719
Biology, Molecular.

Bcl-2 proteins in human lung cancer: Molecular heterogeneity and prognostic value.
LDR:02995nam 2200289 a 45 001 927753
005 20110425
008 110425s2002 eng d
020 $a 0493657223
035 $a (UnM)AAI3051190
035 $a AAI3051190
040 $a UnM $c UnM
100 1 $a Huang, Chris Ing-yi. $3 1251316
245 1 0 $a Bcl-2 proteins in human lung cancer: Molecular heterogeneity and prognostic value.
300 $a 121 p.
500 $a Adviser: David C. Christiani.
500 $a Source: Dissertation Abstracts International, Volume: 63-04, Section: B, page: 1792.
502 $a Thesis (Ph.D.)--Harvard University, 2002.
520 $a The objective of this study is the investigation of the prognostic value of the 27 kD Bcl-2 protein in non-small cell lung cancer (NSCLC) patients. Currently, controversy surrounds the prognostic value of Bcl-2 in lung cancer. We argue that the method of Bcl-2 protein detection might have relevance, as multiple molecular forms of the protein are known to exist. In contrast to immunohistochemistry, the technique used by other investigators, we used Western blot, a more quantifiable method, to analyze Bcl-2 protein, and examined the prognostic value of the presence of Bcl-2 protein in uninvolved lung and in tumor tissues. We also compared adenocarcinoma and squamous cell carcinoma patients, and studied stage I versus stage II tumor patients.
520 $a We studied 91 lung cancer patients. The number of adenocarcinoma and squamous cell carcinoma patients was 45 and 36 respectively, 77% of the patients were of tumor stages I and II and 50% of the patients had relatively small (<4 cm) tumors. Our main findings—the presence of the 27 kD Bcl-2 protein expression in uninvolved lung tissue and in uninvolved lung tissue or tumor combined—was associated with shorter survival. The association was stronger in stage I patients, as 27 kD Bcl-2 expression in uninvolved lung tissue was associated with poor survival after adjusting for other covariates. We found no association between 27 kD Bcl-2 protein expression in the tumor and disease prognosis. In uninvolved lung tissue, 27 kD Bcl-2 protein expression was associated with shorter survival in adenocarcinoma patients, but not in squamous cell carcinoma patients. This is the first report on investigating Bcl-2 protein expression in uninvolved lung tissue as a prognostic marker for NSCLC. In particular, our observation is especially novel because comparison at the level of molecular identity (as 27kD Bcl-2) has not been previously reported in the literature. These findings are of potential clinical application, as identification of risk factors associated with poor survival could be informative for patient management.
590 $a School code: 0084.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0307
690 $a 0992
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 63-04B.
790 $a 0084
790 1 0 $a Christiani, David C., $e advisor
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3051190