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Characterization of Kaposi's sarcoma...

Poole, Lynn Janet.

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Characterization of Kaposi's sarcoma associated herpesvirus (KSHV) infection of primary effusion lymphoma cell lines and dermal microvascular endothelial cells.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Characterization of Kaposi's sarcoma associated herpesvirus (KSHV) infection of primary effusion lymphoma cell lines and dermal microvascular endothelial cells./
作者:	Poole, Lynn Janet.
面頁冊數:	232 p.
附註:	Adviser: Gary S. Hayward.
Contained By:	Dissertation Abstracts International62-10B.
標題:	Biology, Microbiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3028317
ISBN:	049340368X

Characterization of Kaposi's sarcoma associated herpesvirus (KSHV) infection of primary effusion lymphoma cell lines and dermal microvascular endothelial cells.
Poole, Lynn Janet.

Characterization of Kaposi's sarcoma associated herpesvirus (KSHV) infection of primary effusion lymphoma cell lines and dermal microvascular endothelial cells. - 232 p.

Adviser: Gary S. Hayward.

Thesis (Ph.D.)--The Johns Hopkins University, 2002.

Kaposi's sarcoma associated herpesvirus (KSHV, or Human Herpesvirus 8, HHV8) is the most recently discovered human herpesvirus. It belongs to the gamma-2 herpesviridae family and is closely related to herpesvirus saimiri (HVS) and more distantly related to the gamma-1 human herpesvirus, Epstein Barr Virus (EBV). Due to the lack of a susceptible cell type for infection, characterization of KSHV gene expression was initially dependent upon the use of latently infected pleural effusion lymphoma (PEL) cell lines derived from AIDS patients. However, the development of endothelial cell culture systems enabled the characterization of viral infection from initial stages, as well as cellular response to viral infection.

ISBN: 049340368XSubjects--Topical Terms:

1017734
Biology, Microbiology.

Characterization of Kaposi's sarcoma associated herpesvirus (KSHV) infection of primary effusion lymphoma cell lines and dermal microvascular endothelial cells.
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245 1 0 $a Characterization of Kaposi's sarcoma associated herpesvirus (KSHV) infection of primary effusion lymphoma cell lines and dermal microvascular endothelial cells.
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520 $a Kaposi's sarcoma associated herpesvirus (KSHV, or Human Herpesvirus 8, HHV8) is the most recently discovered human herpesvirus. It belongs to the gamma-2 herpesviridae family and is closely related to herpesvirus saimiri (HVS) and more distantly related to the gamma-1 human herpesvirus, Epstein Barr Virus (EBV). Due to the lack of a susceptible cell type for infection, characterization of KSHV gene expression was initially dependent upon the use of latently infected pleural effusion lymphoma (PEL) cell lines derived from AIDS patients. However, the development of endothelial cell culture systems enabled the characterization of viral infection from initial stages, as well as cellular response to viral infection.
520 $a Initial characterization of KSHV infection entailed analysis of transcription of herpesvirus gene transcripts using primer extension methods to map the 5<super>′</super> ends of mRNA transcripts. Through this analysis, viral genes could be characterized as latent, early, or late depending on their expression during the viral life cycle as imposed by TPA. Further cloning and analysis of three of the membrane receptor-type proteins encoded by KSHV, the ORF K1, ORF K15, and vGCR was performed to better understand the expression of specific viral transcripts.
520 $a Finally, to study cellular responses to viral infection, cellular gene expression was evaluated using DNA microarrays. This initial characterization was one of the first global examinations of KSHV infection of endothelial cells reported, and one of the first DNA microarray characterizations of viral effects on cellular gene expression. This technology identified large families of genes, including the interferons, which were upregulated in response to KSHV infection of endothelial cells, and the compilation of these results will lead to an increased understanding of how the virus dysregulates cell growth thereby causing cancer.
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