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Antimutagenesis and antioxidation by...

Shih, Meng-Ta Peter.

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Antimutagenesis and antioxidation by phenolic compounds.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Antimutagenesis and antioxidation by phenolic compounds./
作者:	Shih, Meng-Ta Peter.
面頁冊數:	290 p.
附註:	Source: Dissertation Abstracts International, Volume: 58-10, Section: B, page: 5256.
Contained By:	Dissertation Abstracts International58-10B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9811330
ISBN:	0591620154

Antimutagenesis and antioxidation by phenolic compounds.
Shih, Meng-Ta Peter.

Antimutagenesis and antioxidation by phenolic compounds. - 290 p.

Source: Dissertation Abstracts International, Volume: 58-10, Section: B, page: 5256.

Thesis (Ph.D.)--University of Kansas, 1997.

These results and others indicate that cinnamyl acids, cinnamyl esters, curcumin, epigallocatechin gallate, and coumarin derivatives, in addition to their documented usefulness, warrant further study as antimutagenic agents.

ISBN: 0591620154Subjects--Topical Terms:

1017730
Biology, Genetics.

Antimutagenesis and antioxidation by phenolic compounds.
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100 1 $a Shih, Meng-Ta Peter. $3 1251181
245 1 0 $a Antimutagenesis and antioxidation by phenolic compounds.
300 $a 290 p.
500 $a Source: Dissertation Abstracts International, Volume: 58-10, Section: B, page: 5256.
502 $a Thesis (Ph.D.)--University of Kansas, 1997.
520 $a These results and others indicate that cinnamyl acids, cinnamyl esters, curcumin, epigallocatechin gallate, and coumarin derivatives, in addition to their documented usefulness, warrant further study as antimutagenic agents.
520 $a Understanding how antimutagens modulate nucleic acid damage is an important issue. We used a simple colorimetric genotoxicity assay to monitor the induction of the repair genes in Escherichia coli K$\sb{12}.$ The above assay was utilized to evaluate whether or not cinnamyl acids (e.g., cinnamic acid, caffeic acid, ferulic acid, chlorogenic acid), cinnamyl esters (e.g., plicatin B), curcumin, epigallocatechin gallate, and coumarin derivatives (e.g., asacoumarin B) have any effect on DNA repair processes in bacterial strains. All of these compounds were tested using a strain transformed with plasmids carrying different lacZ fusion constructs under the control of a gene involved in either the SOS (e.g., recA) or adaptive regulons (e.g., ada). In these experiments, ferulic acid, plicatin B, and asacoumarin B down modulated 4-nitroquinoline 1-oxide and methyl methanesulfonate induced DNA damages. We also found that ferulic acid, plicatin B, and asacoumarin B down modulated hydrogen peroxide induced DNA damages in the E. coli strains. These inhibitions may be due to the suppression of the recA-regulated SOS response in bacteria. We have also verified their chemopreventive potentials in the modified Ames test utilizing the S. typhimurium TA100 strain. However, it seemed that in general the modified Ames tests were less sensitive as compared to the colorimetric genotoxicity assays in identifying potential chemopreventive agents against known mutagens.
520 $a Antioxidants can also play a crucial role in mutagenesis and can act by direct interaction with mutagens. To assay for antioxidative properties, the hypoxanthine-xanthine oxidase, the xanthine-xanthine oxidase and the phenazine methosulfate/NADH assays are most commonly used. The antioxidant properties of these phenolic compounds and their inhibitory effects on the xanthine-oxidizing enzyme were investigated. The results suggest that these "natural" antimutagens may function by several mechanisms, including superoxide scavenging, an antioxidant function.
520 $a One of the main concerns of today is the development of antibiotic resistant bacteria. One of the ways bacteria develop antibiotic resistance is by target modification obtained through mutations. From a practical standpoint, we decided to examine whether these natural plant compounds can prevent the development of bacterial antibiotic resistance due to target modification. In our studies we found that caffeic acid, ferulic acid, chlorogenic acid, plicatin B, SRM-I-27, asacoumarin B, and TH-4-215 B have the potential to prevent the development of streptomycin resistant Salmonella typhimurium TA100 induced by methyl methanesulfonate.
590 $a School code: 0099.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Microbiology. $3 1017734
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710 2 0 $a University of Kansas. $3 626626
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790 $a 0099
791 $a Ph.D.
792 $a 1997
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