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Cell death pathways in irradiated pr...

Bromfield, Gillian Patricia.

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Cell death pathways in irradiated prostate cells.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Cell death pathways in irradiated prostate cells./
作者:	Bromfield, Gillian Patricia.
面頁冊數:	89 p.
附註:	Adviser: Robert G. Bristow.
Contained By:	Masters Abstracts International41-03.
標題:	Biology, Cell. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ74050
ISBN:	0612740501

Cell death pathways in irradiated prostate cells.
Bromfield, Gillian Patricia.

Cell death pathways in irradiated prostate cells. - 89 p.

Adviser: Robert G. Bristow.

Thesis (M.Sc.)--University of Toronto (Canada), 2002.

In this thesis, the molecular and cellular responses following ionizing radiation of two normal and three malignant prostate cell lines were determined to further understand the clinical response of prostate cancer to radiotherapy. Relative levels of apoptosis, clonogenic survival and permanent-cell cycle arrest were determined amongst the cultures, as well as molecular data pertaining to cell-cycle checkpoints and apoptosis. Radiation-induced apoptosis was minimal in all cell lines and did not correlate with results from clonogenic survival, suggesting that apoptosis is not the dominant mode of radiation-induced cell killing in prostate tissues <italic>in vitro</italic>. Expression data confirmed a p53-dependent induction of p21<super>WAF1</super>, but the levels of bax or bcl-2 observed did not correlate with apoptosis or long-term survival data. Furthermore, these results suggest that proliferative arrest is a critical endpoint for these experiments. Future strategies for predicting the response of prostate cancer to radiotherapy should focus on factors that determine permanent cell cycle arrest following irradiation.

ISBN: 0612740501Subjects--Topical Terms:

1017686
Biology, Cell.

Cell death pathways in irradiated prostate cells.
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502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2002.
520 $a In this thesis, the molecular and cellular responses following ionizing radiation of two normal and three malignant prostate cell lines were determined to further understand the clinical response of prostate cancer to radiotherapy. Relative levels of apoptosis, clonogenic survival and permanent-cell cycle arrest were determined amongst the cultures, as well as molecular data pertaining to cell-cycle checkpoints and apoptosis. Radiation-induced apoptosis was minimal in all cell lines and did not correlate with results from clonogenic survival, suggesting that apoptosis is not the dominant mode of radiation-induced cell killing in prostate tissues <italic>in vitro</italic>. Expression data confirmed a p53-dependent induction of p21<super>WAF1</super>, but the levels of bax or bcl-2 observed did not correlate with apoptosis or long-term survival data. Furthermore, these results suggest that proliferative arrest is a critical endpoint for these experiments. Future strategies for predicting the response of prostate cancer to radiotherapy should focus on factors that determine permanent cell cycle arrest following irradiation.
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