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Bioinformatics identification of cod...

Park, Jane.

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Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers./
作者:	Park, Jane.
面頁冊數:	143 p.
附註:	Adviser: Mark Redston.
Contained By:	Masters Abstracts International40-03.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MQ63104
ISBN:	0612631044

Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers.
Park, Jane.

Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers. - 143 p.

Adviser: Mark Redston.

Thesis (M.Sc.)--University of Toronto (Canada), 2001.

High frequency microsatellite instability (MSI-H) colorectal carcinomas (CRCs) display MMR deficiency and account for about 15% of human colorectal cancers. Gene inactivation via mononucleotide tract frameshift mutations is characteristic of the pathogenesis of MSI-H colorectal carcinomas. Frameshift mutations have only been described in selected candidate genes including <italic> TGFβRII, IGFIIR, BAX</italic> and others. We developed “Kangaroo”, a program capable of highly specialized searches in nucleotide and protein sequence databases. Utilizing Kangaroo, we identified genes with coding polyadenine tracts that had functional significance in cell cycle regulation. Our results revealed widespread novel mutations in mismatch repair deficient colorectal cancers, while Kangaroo provided a method for genome scanning to identify candidate mutation hot spots in evolution and human disease.

ISBN: 0612631044Subjects--Topical Terms:

1017730
Biology, Genetics.

Bioinformatics identification of coding microsatellites that are mutated in mismatch repair-deficient colorectal cancers.
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