東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Apoptosis and aging in Drosophila.

Queen's University (Canada)., Biology.

FindBook

Google Book

Amazon

博客來

Apoptosis and aging in Drosophila.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Apoptosis and aging in Drosophila./
作者:	Zheng, Jie.
面頁冊數:	191 p.
附註:	Source: Dissertation Abstracts International, Volume: 69-12, Section: B, page: 7272.
Contained By:	Dissertation Abstracts International69-12B.
標題:	Biology, Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR44568
ISBN:	9780494445686

Apoptosis and aging in Drosophila.
Zheng, Jie.

Apoptosis and aging in Drosophila. - 191 p.

Source: Dissertation Abstracts International, Volume: 69-12, Section: B, page: 7272.

Thesis (Ph.D.)--Queen's University (Canada), 2008.

Several genes involved in the regulation of apoptosis can influence longevity. Although observations in several different systems imply that apoptosis and aging are closely linked, the relationship between the two remains largely unknown. In this study, Drosophila melanogaster was used as a model organism to explore the relationship between aging and apoptosis regulation. Apoptosis was investigated using two apoptotic hallmarks: caspase activity and DNA fragmentation. The results showed that apoptosis occured in adult flies at all ages and the changes in apoptosis associated with aging were linked to physiological age and were tissue-specific. During normal fly aging, apoptosis increased gradually within the muscle and was activated in the fat of old flies. However, neither of the two apoptotic signs were shown in the nervous system. The analysis of the apoptotic response to starvation and oxidative stress suggested that the increased apoptosis in muscle resulted from the accumulation of oxidative damage associated with aging. Once the presence of apoptosis during Drosophila aging was confirmed, the expression of anti-apoptotic genes was manipulated in specific tissues to examine the impact of a localized alternation of apoptosis on aging. The overexpression of anti-apoptotic genes in muscle extended Drosophila mean and maximum life span up to 99% and 65%, respectively. This extension was mediated by apoptosis inhibition using the detection of caspase activity and DNA fragmentation. In addition, the long-lived animals exhibited increased resistance to oxidative stress and preserved flight ability. Overall this study establishes that muscle apoptosis limits life span and participates in sarcopenia. This finding may have applications in the development of interventions to improve the life quality of elderly human.

ISBN: 9780494445686Subjects--Topical Terms:

1017730
Biology, Genetics.

Apoptosis and aging in Drosophila.
LDR:02581nmm 2200241 a 45 001 886946
005 20101013
008 101013s2008 ||||||||||||||||| ||eng d
020 $a 9780494445686
035 $a (UMI)AAINR44568
035 $a AAINR44568
040 $a UMI $c UMI
100 1 $a Zheng, Jie. $3 1058666
245 1 0 $a Apoptosis and aging in Drosophila.
300 $a 191 p.
500 $a Source: Dissertation Abstracts International, Volume: 69-12, Section: B, page: 7272.
502 $a Thesis (Ph.D.)--Queen's University (Canada), 2008.
520 $a Several genes involved in the regulation of apoptosis can influence longevity. Although observations in several different systems imply that apoptosis and aging are closely linked, the relationship between the two remains largely unknown. In this study, Drosophila melanogaster was used as a model organism to explore the relationship between aging and apoptosis regulation. Apoptosis was investigated using two apoptotic hallmarks: caspase activity and DNA fragmentation. The results showed that apoptosis occured in adult flies at all ages and the changes in apoptosis associated with aging were linked to physiological age and were tissue-specific. During normal fly aging, apoptosis increased gradually within the muscle and was activated in the fat of old flies. However, neither of the two apoptotic signs were shown in the nervous system. The analysis of the apoptotic response to starvation and oxidative stress suggested that the increased apoptosis in muscle resulted from the accumulation of oxidative damage associated with aging. Once the presence of apoptosis during Drosophila aging was confirmed, the expression of anti-apoptotic genes was manipulated in specific tissues to examine the impact of a localized alternation of apoptosis on aging. The overexpression of anti-apoptotic genes in muscle extended Drosophila mean and maximum life span up to 99% and 65%, respectively. This extension was mediated by apoptosis inhibition using the detection of caspase activity and DNA fragmentation. In addition, the long-lived animals exhibited increased resistance to oxidative stress and preserved flight ability. Overall this study establishes that muscle apoptosis limits life span and participates in sarcopenia. This finding may have applications in the development of interventions to improve the life quality of elderly human.
590 $a School code: 0283.
650 4 $a Biology, Genetics. $3 1017730
690 $a 0369
710 2 $a Queen's University (Canada). $b Biology. $3 1058665
773 0 $t Dissertation Abstracts International $g 69-12B.
790 $a 0283
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR44568