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Experimental and theoretical studies...

University of South Carolina.

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Experimental and theoretical studies of implant assisted magnetic drug targeting.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Experimental and theoretical studies of implant assisted magnetic drug targeting./
Author:	Aviles, Misael O.
Description:	207 p.
Notes:	Adviser: James A. Ritter.
Contained By:	Dissertation Abstracts International69-07B.
Subject:	Biophysics, Medical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3321384
ISBN:	9780549710332

Experimental and theoretical studies of implant assisted magnetic drug targeting.
Aviles, Misael O.

Experimental and theoretical studies of implant assisted magnetic drug targeting. - 207 p.

Adviser: James A. Ritter.

Thesis (Ph.D.)--University of South Carolina, 2008.

One way to achieve drug targeting in the body is to incorporate magnetic nanoparticles into drug carriers and then retain them at the site using an externally applied magnetic field. This process is referred to as magnetic drug targeting (MDT). However, the main limitation of MDT is that an externally applied magnetic field alone may not be able to retain a sufficient number of magnetic drug carrier particles (MDCPs) to justify its use. Such a limitation might not exist when high gradient magnetic separation (HGMS) principles are applied to assist MDT by means of ferromagnetic implants. It was hypothesized that an Implant Assisted -- MDT (IA-MDT) system would increase the retention of the MDCPs at a target site where an implant had been previously located, since the magnetic forces are produced internally. With this in mind, the overall objective of this work was to demonstrate the feasibility of an IA-MDT system through mathematical modeling and in vitro experimentation. The mathematical models were developed and used to demonstrate the behavior and limitations of IA-MDT, and the in vitro experiments were designed and used to validate the models and to further elucidate the important parameters that affect the performance of the system. IA-MDT was studied with three plausible implants, ferromagnetic stents, seed particles, and wires. All implants were studied theoretically and experimentally using flow through systems with polymer particles containing magnetite nanoparticles as MDCPs. In the stent studies, a wire coil or mesh was simply placed in a flow field and the capture of the MDCPs was studied. In the other cases, a porous polymer matrix was used as a surrogate capillary tissue scaffold to study the capture of the MDCPs using wires or particle seeds as the implant, with the seeds either fixed within the polymer matrix or captured prior to capturing the MDCPs. An in vitro heart tissue perfusion model was also used to study the use of stents. In general, all the results demonstrated that IA-MDT is indeed feasible and that careful modification of the MDCP properties and implant properties are fundamental to the success of this technology.

ISBN: 9780549710332Subjects--Topical Terms:

1017681
Biophysics, Medical.

Experimental and theoretical studies of implant assisted magnetic drug targeting.
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020 $a 9780549710332
035 $a (UMI)AAI3321384
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100 1 $a Aviles, Misael O. $3 1036233
245 1 0 $a Experimental and theoretical studies of implant assisted magnetic drug targeting.
300 $a 207 p.
500 $a Adviser: James A. Ritter.
500 $a Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4297.
502 $a Thesis (Ph.D.)--University of South Carolina, 2008.
520 $a One way to achieve drug targeting in the body is to incorporate magnetic nanoparticles into drug carriers and then retain them at the site using an externally applied magnetic field. This process is referred to as magnetic drug targeting (MDT). However, the main limitation of MDT is that an externally applied magnetic field alone may not be able to retain a sufficient number of magnetic drug carrier particles (MDCPs) to justify its use. Such a limitation might not exist when high gradient magnetic separation (HGMS) principles are applied to assist MDT by means of ferromagnetic implants. It was hypothesized that an Implant Assisted -- MDT (IA-MDT) system would increase the retention of the MDCPs at a target site where an implant had been previously located, since the magnetic forces are produced internally. With this in mind, the overall objective of this work was to demonstrate the feasibility of an IA-MDT system through mathematical modeling and in vitro experimentation. The mathematical models were developed and used to demonstrate the behavior and limitations of IA-MDT, and the in vitro experiments were designed and used to validate the models and to further elucidate the important parameters that affect the performance of the system. IA-MDT was studied with three plausible implants, ferromagnetic stents, seed particles, and wires. All implants were studied theoretically and experimentally using flow through systems with polymer particles containing magnetite nanoparticles as MDCPs. In the stent studies, a wire coil or mesh was simply placed in a flow field and the capture of the MDCPs was studied. In the other cases, a porous polymer matrix was used as a surrogate capillary tissue scaffold to study the capture of the MDCPs using wires or particle seeds as the implant, with the seeds either fixed within the polymer matrix or captured prior to capturing the MDCPs. An in vitro heart tissue perfusion model was also used to study the use of stents. In general, all the results demonstrated that IA-MDT is indeed feasible and that careful modification of the MDCP properties and implant properties are fundamental to the success of this technology.
590 $a School code: 0202.
650 4 $a Biophysics, Medical. $3 1017681
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Physics, Electricity and Magnetism. $3 1019535
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690 $a 0607
690 $a 0760
710 2 $a University of South Carolina. $3 1017477
773 0 $t Dissertation Abstracts International $g 69-07B.
790 $a 0202
790 1 0 $a Ritter, James A., $e advisor
791 $a Ph.D.
792 $a 2008
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3321384